438569-39-2

Basic information

• Product Name: 2-Methoxy-6-((E)-propenyl)-benzoic acid 2,6-diisopropyl-phenyl ester
• Synonyms: 2-Methoxy-6-((E)-propenyl)-benzoic acid 2,6-diisopropyl-phenyl ester
• CAS NO: 438569-39-2
• Molecular Weight: 352.474
• Mol File: 438569-39-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Methoxy-6-((E)-propenyl)-benzoic acid 2,6-diisopropyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-6-((E)-propenyl)-benzoic acid 2,6-diisopropyl-phenyl ester(438569-39-2)
• EPA Substance Registry System: 2-Methoxy-6-((E)-propenyl)-benzoic acid 2,6-diisopropyl-phenyl ester(438569-39-2)

Safety Data

• Hazardous Substances Data: 438569-39-2(Hazardous Substances Data)

Upstream product

• 438569-38-1 2-methoxy-6-propenyl-benzoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 215023-79-3 2,6-di-tert-butyl-4-methoxyphenyl 2,6-dimethoxybenzoic acid ester 
• 2078-54-8 2,6-diisopropylphenol 
• 143112-20-3 2-methoxy-6-((E)-prop-1-enyl)benzoic acid 

Downstream Products

• 438569-40-5 2',4',6'-Trimethyl-3-((E)-propenyl)-biphenyl-2-carboxylic acid 2,6-diisopropyl-phenyl ester 
• 438569-42-7 2-methyl-7-(2,4,6-trimethyl-phenyl)-inden-1-one 

Relevant articles and documents

7-Mesityl-2,2-dimethylindan-1-ol: A novel alcohol which serves as both a chiral auxiliary and a protective group for carboxy functions

A novel chiral indanol 11 is conveniently synthesized by using a stepwise displacement of the methoxy groups of 2,6-dimethoxybenzoic ester 1 by a vinyl and then an aryl Grignard reagent as the key step. The racemic indanol 11 is optically resolved as the diastereomeric (Sa)-2′-methoxy-1,1′-binaphthyl-2-carboxylic esters 12 by column chromatography. The absolute stereochemistry of the indanol (+)-11 is established to be S by an X-ray crystallographic analysis of the ester (Sa,S)-12. Performance of the indanol 11 as a chiral auxiliary, and as a protective group for the carboxy function, is examined in the atrolactic acid synthesis from phenylglyoxylic ester 13 and methylmagnesium iodide and in the biphenyl coupling reaction of 2,3-dimethoxybenzoic ester 15 with 2-methoxy-4,6-dimethylphenylmagnesium bromide, resulting in quantitative formations of atrolactic ester 14 with up to 83% de and biphenyl 16 with 72% de, respectively.