439858-37-4 Usage
Description
1-Acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine is a complex organic compound characterized by its acyl-protected hydroxylamine structure. This unique molecular configuration allows it to function as a versatile intermediate in various chemical reactions and applications, particularly in the field of biochemistry and imaging.
Uses
Used in Biochemistry Research:
1-Acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine is used as a spin label generator for electron paramagnetic resonance (EPR) brain imaging. Its role in this application is crucial for enhancing the understanding of brain function and the development of new diagnostic and therapeutic approaches.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 1-Acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine serves as a key intermediate in the synthesis of various drug candidates. Its acyl-protected hydroxylamine structure makes it a valuable building block for creating novel compounds with potential therapeutic applications.
Used in Chemical Synthesis:
1-Acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine is utilized as a versatile intermediate in organic synthesis. Its unique structure allows for the development of new synthetic pathways and the creation of a wide range of chemical products, including specialty chemicals and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 439858-37-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,9,8,5 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 439858-37:
(8*4)+(7*3)+(6*9)+(5*8)+(4*5)+(3*8)+(2*3)+(1*7)=204
204 % 10 = 4
So 439858-37-4 is a valid CAS Registry Number.
439858-37-4Relevant articles and documents
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging
Yordanov, Alexander T.,Yamada, Ken-Ichi,Krishna, Murali C.,Russo, Angelo,Yoo, John,English, Sean,Mitchell, James B.,Brechbiel, Martin W.
, p. 2283 - 2288 (2007/10/03)
In a search for novel electron paramagnetic resonance (EPR) brain imaging agents, we have designed and synthesized the acyl-protected hydroxylamines 1-acetoxy-4-methoxycarbonyl-2,2,6,6-tetramethylpiperidine (AMCPe), 1-acetoxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (AMCPy), and 1-acetoxy-3-(acetoxymethoxy)carbonyl-2,2,5,5-tetramethylpyrrolidine (DACPy), in which both the ring size and the number of ester functions were varied. In all of them, the nitroxide was first reduced and the resultant hydroxylamine was then protected with an acetyl group. These compounds are lipophilic, which is a major prerequisite for blood-brain barrier penetration. Once in the brain, esterases and oxidants quickly convert these derivatives into ionic, water-soluble radicals and thus EPR detectable species that then reside in the central nervous system for periods of time sufficient for detection and imaging. The biological relevancy of these new compounds in mice has been assessed, and their biodistribution patterns have been compared. The five-membered ring derivative AMCPy emerged as a potent EPR brain imaging agent while the other two derivatives, AMCPe and DACPy, were quite ineffective.