440370-30-9

Basic information

• Product Name: (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide
• Synonyms: (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide
• CAS NO: 440370-30-9
• Molecular Weight: 319.351
• Mol File: 440370-30-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide(440370-30-9)
• EPA Substance Registry System: (1R,2R)-2-(3,4-difluorophenyl)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl acetamide(440370-30-9)

Safety Data

• Hazardous Substances Data: 440370-30-9(Hazardous Substances Data)

Upstream product

• 658-93-5 (3,4-difluorophenyl)acetic acid 
• 321-97-1 (1R,2R)-pseudoephedrine 

Downstream Products

• 440370-41-2 4-(R)-(3,4-difluorophenyl)-4-{N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylcarbamoyl}-3-(R)-(4-methoxyphenoxymethyl)butyric acid methyl ester 
• 855316-57-3 2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide 
• 440370-50-3 3-(R)-(3,4-difluorophenyl)-4-(R)-(4-methoxyphenoxymethyl)tetrahydro-2H-pyran-2-one 
• 855316-64-2 1-[3-(R)-(3,4-difluorophenyl)-2-(4-nitrobenzoyloxy)tetrahydro-2H-pyran-4(R)-ylmethyl]-3-(R)-methylpiperidine-3-carboxylic acid ethyl ester 
• 855316-62-0 3-(R)-methyl-1-[2-oxo-3-(R)-(3,4-difluorophenyl)tetrahydro-2H-pyran-4(R)-ylmethyl]piperidine-3-carboxylic acid ethyl ester 
• 855316-63-1 1-[3-(R)-(3,4-difluorophenyl)-2-hydroxytetrahydro-2H-pyran-4(R)-ylmethyl]-3-(R)-methylpiperidine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of a tetrahydropyran NK1 receptor antagonist via asymmetric conjugate addition

Two asymmetric syntheses of the NK1 receptor antagonist 1-[2-(R)-{1-(R)-[3,5-bis(trifluoromethyl)-phenyl]ethoxy}-3-(R)-(3, 4-difluorophenyl)-4-(R)-tetrahydro-2H-pyran-4-ylmethyl]-3-(R) -methylpiperidine-3-carboxylic acid (1) were developed. In