4414-76-0

Basic information

• Product Name: 1H-indole-3-propiononitrile
• Synonyms: 1H-indole-3-propiononitrile;1H-Indole-3-propanenitrile;3-(1H-Indole-3-yl)propanenitrile;Einecs 224-572-8;3-(1H-Indol-3-yl)propionitrile
• CAS NO: 4414-76-0
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.2105
• EINECS: 224-572-8
• Mol File: 4414-76-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 64 °C
• Boiling Point: 410.7°Cat760mmHg
• Flash Point: 136°C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 5.92E-07mmHg at 25°C
• Refractive Index: 1.648
• PKA: 16.94±0.30(Predicted)
• CAS DataBase Reference: 1H-indole-3-propiononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-indole-3-propiononitrile(4414-76-0)
• EPA Substance Registry System: 1H-indole-3-propiononitrile(4414-76-0)

Safety Data

• Hazardous Substances Data: 4414-76-0(Hazardous Substances Data)

Usage

General Description

1H-indole-3-propiononitrile, also known as 3-(1H-indol-3-yl)propanenitrile, is an organic compound with the molecular formula C11H9N. It is a nitrile derivative of indole, which is a heterocyclic aromatic compound commonly found in plants and is known for its diverse biological activities. 1H-indole-3-propiononitrile has been studied for its potential pharmaceutical properties, including its anti-inflammatory and anti-cancer activities. It has also been investigated as a precursor in the synthesis of various indole derivatives. Its chemical structure and properties make it a valuable compound for research and potential drug development.

InChI:InChI=1/C11H10N2/c12-7-3-4-9-8-13-11-6-2-1-5-10(9)11/h1-2,5-6,8,13H,3-4H2

Upstream product

• 120-72-9 indole 
• 107-13-1 acrylonitrile 
• 542-76-7 3-Chloropropionitrile 
• 90896-22-3 3-(trimethylsilyl)-1H-indole 
• 700-06-1 indole-3-carbinol 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 59409-14-2 3-(3-indolyl)propanal oxime 
• 487-89-8 Indole-3-carboxaldehyde 
• 85452-79-5 (Z)-3-(1H-indol-3-yl)acrylonitrile 
• 157977-13-4 Indol-3-ylmethylmalonsaeuredinitril 

Downstream Products

• 830-96-6 Indole-3-propionic acid 
• 6245-89-2 Homotryptamine 
• 87400-38-2 N-benzyl-3-(1H-indol-3-yl)propan-1-amine 
• 360788-10-9 benzyl-[3-(1H-indol-3-yl)-propyl]-carbamic acid tert-butyl ester 
• 360788-11-0 2-{3-[3-(benzyl-tert-butoxycarbonyl-amino)-propyl]-1H-indol-2-yl}-malonic acid dimethyl ester 
• 360787-58-2 (4aR,5R,12bS)-methyl 4-benzyl-1,2,3,4,4a,5,6,8-octahydro-5-[(2S)-2-methyl-2,3-(carbonyldioxy)propyl]-pyrido[2,3-d]carbazol-7-carboxylate 
• 361202-03-1 4-benzyl-7-chloro-5-(4-ethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,2,3,4,4a,5,6,7-octahydro-pyrido[2,3-d]carbazole-7-carboxylic acid methyl ester 
• 361202-04-2 4-benzyl-7-chloro-5-[2-(toluene-4-sulfonyloxymethyl)-2-trimethylsilanyloxy-butyl]-1,2,3,4,4a,5,6,7-octahydro-pyrido[2,3-d]carbazole-7-carboxylic acid methyl ester 
• 360787-50-4 C₅₇H₇₂N₄O₁₀ 
• 360787-60-6 C₆₄H₈₂N₄O₁₂SSi 
• 360787-63-9 3-[3-[((S)-α-methylbenzyl)amino]propyl]indole 
• 360787-44-6 methyl 3-benzyl-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate 

Relevant articles and documents

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Access to Spirocyclized Oxindoles and Indolenines via Palladium-Catalyzed Cascade Reactions of Propargyl Carbonates with 2-Oxotryptamines and Tryptamines

(Chemical Equation Presented). Reported here are methods for the direct construction of a range of spirocyclized oxindoles and indolenines in good to excellent yields. Specifically, we report the palladium-catalyzed reactions of oxindoles and indoles, both functioning as bis-nucleophiles, with propargyl carbonates to afford spirocyclic products having an exocyclic double bond on the newly formed ring. The reaction proceeds through a process wherein the first nucleophilic unit on the oxindole or indole reacts with an allenyl-palladium species, formed from oxidative addition of Pd(0) to propargyl carbonates, to generate a π-allyl palladium intermediate that then reacts further with the second nucleophilic component of the oxindole or indole. The cascade process forges two bonds en route to spirocyclized oxindole and indolenine products. The use of chiral phosphines renders the cyclization sequence enantioselective, providing spirocyclic products with modest to good enantioselectivities.

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase (TDO), an unrelated hepatic enzyme also catalyzing the first step of tryptophan degradation, is also expressed in many tumors and that this expression prevents tumor rejection by locally depleting tryptophan. Herein, we report a structure-activity study on a series of 3-(2-(pyridyl)ethenyl)indoles. More than 70 novel derivatives were synthesized, and their TDO inhibitory potency was evaluated. The rationalization of the structure-activity relationships (SARs) revealed essential features to attain high TDO inhibition and notably a dense H-bond network mainly involving His55 and Thr254 residues. Our study led to the identification of a very promising compound (58) displaying good TDO inhibition (Ki = 5.5 μM), high selectivity, and good oral bioavailability. Indeed, 58 was chosen for preclinical evaluation.