4423-74-9

Basic information

• Product Name: N-(2-NAPHTHYL)FORMAMIDE 97
• Synonyms: N-(2-NAPHTHYL)FORMAMIDE 97
• CAS NO: 4423-74-9
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.198
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 4423-74-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 126-130 °C(lit.)
• Boiling Point: 386.5°Cat760mmHg
• Flash Point: 227.8°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 3.53E-06mmHg at 25°C
• Refractive Index: 1.694
• PKA: 15.00±0.30(Predicted)
• CAS DataBase Reference: N-(2-NAPHTHYL)FORMAMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-NAPHTHYL)FORMAMIDE 97(4423-74-9)
• EPA Substance Registry System: N-(2-NAPHTHYL)FORMAMIDE 97(4423-74-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36-42/43
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 4423-74-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9NO/c13-8-12-11-6-5-9-3-1-2-4-10(9)7-11/h1-8H,(H,12,13)

Upstream product

• 70-18-8 glutathion 
• 10124-78-4 2-napthylisocyanide 

Downstream Products

• 861604-80-0 2-phenyl-benzo[f]quinoline-1-carboxylic acid 
• 613-46-7 2-naphthalenecarbonitrile 
• 10124-78-4 2-napthylisocyanide 
• 2437-03-8 2-ethylaminonaphthalene 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?

Despite the isolation of hundreds of bioactive isocyanides from terrestrial fungi and bacteria as well as marine organisms, the isocyanide functionality has so far received little attention from a medicinal chemistry standpoint. The widespread tenet that isocyanides are chemically and metabolically unstable has restricted bioactivity studies to their antifouling properties and technical applications. In order to confirm or refute this idea, the hepatic metabolism of six model isocyanides was investigated. Aromatic and primary isocyanides turned out to be unstable and metabolically labile, but secondary and tertiary isocyanides resisted metabolization, showing, in some cases, cytochrome P450 inhibitory properties. The potential therefore exists for the secondary and tertiary isocyanides to qualify them as pharmacophore groups, in particular as war-heads for metalloenzyme inhibition because of their potent metal-coordinating properties.