442846-59-5

Basic information

• Product Name: 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline
• Synonyms: 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline
• CAS NO: 442846-59-5
• Molecular Formula: C17H24F3N3O2
• Molecular Weight: 359.39
• Mol File: 442846-59-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.546°C at 760 mmHg
• Flash Point: 205.72°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• PKA: 5.94±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline(442846-59-5)
• EPA Substance Registry System: 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline(442846-59-5)

Safety Data

• Hazardous Substances Data: 442846-59-5(Hazardous Substances Data)

Usage

General Description

3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline is a chemical compound with a long name that consists of a piperazine ring and a trifluoromethyl group. The Boc (tert-butoxycarbonyl) protecting group is attached to the piperazine nitrogen, and the trifluoromethyl group is attached to the aniline ring. 3-(4-Boc-piperazin-1-yl-methyl)-5-trifluoromethylaniline has potential applications in medicinal chemistry and drug development due to its structural features, which can contribute to its pharmacological properties. The presence of the piperazine ring makes it a potential building block for drug molecules, and the trifluoromethyl group can enhance the biological activity of the compound. Overall, this chemical compound has the potential to be used in pharmaceutical research and development.

InChI:InChI=1/C17H24F3N3O2/c1-16(2,3)25-15(24)23-6-4-22(5-7-23)11-12-8-13(17(18,19)20)10-14(21)9-12/h8-10H,4-7,11,21H2,1-3H3

Relevant articles and documents

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.