442882-27-1

Basic information

• Product Name: 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione, 6-[(4-methoxyphenyl)methyl]-
• CAS NO: 442882-27-1
• Molecular Formula: C15H12N2O3
• Molecular Weight: 268.272
• Mol File: 442882-27-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione, 6-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione, 6-[(4-methoxyphenyl)methyl]-(442882-27-1)
• EPA Substance Registry System: 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione, 6-[(4-methoxyphenyl)methyl]-(442882-27-1)

Safety Data

• Hazardous Substances Data: 442882-27-1(Hazardous Substances Data)

Upstream product

• 4664-00-0 2,3-pyridinedicarboximide 
• 2393-23-9 4-methoxy-benzylamine 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 824-94-2 p-methoxybenzyl chloride 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 

Downstream Products

• 158060-81-2 2,8-diazabicyclo[4.3.0]nonane 
• 5654-94-4 2,8-diazabicyclo-[4.3.0]-nonane 
• 929206-61-1 7-acetoxy-6,7-dihydro-6-(4-methoxybenzyl)-5H-pyrrolo[3,4-b]pyridin-5-one 
• 902572-92-3 7-hydroxy-6,7-dihydro-6-(4-methoxybenzyl)-pyrrolo[3,4-b]pyridin-5-one 

Relevant articles and documents

(S, S) - 2,8-diazabicyclo [4.3.0] nonane preparation method

The invention relates to a novel preparation method of (S,S)-2,8-diazabicyclo[4.3.0]. The method comprises the steps that: 2,3-pyridine dicarboxylic acid derivative and amide are subjected to condensation, such that 2,3-pyridine dicarboximide is formed; 2,3-pyridine dicarboximide is subjected to protection and hydrogenation reduction, such that 8-substituted-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is reduced in a borohydride reduction system, such that 8-substituted-2,8-diazabicyclo[4.3.0]nonane is obtained; the product is subjected to optical-active organic acid resolution, such that 8-site protection group is removed, and the final product is obtained. Or, 2,3-pyridine dicarboximide is directly subjected to hydrogenation reduction, such that 7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is produced; the product is directly reduced in a borohydride reduction system, such that 2,8-diazabicyclo[4.3.0]nonane is produced; the 2,8-diazabicyclo[4.3.0]nonane is subjected to optical-active organic acid resolution, such that the final product is directly obtained. The method provided by the invention is advantaged in simple reaction route. The raw materials are cheap and easy to obtain. The reaction conditions are mild and easy to control. The method is suitable for industrialized productions.

Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study

Versatile method has been developed for synthesis of N-substituted imides. Thus, acid anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative cyclization with substituted amines using DPPOx and Et3N to afford N-substituted imides under mild conditions. The DNA binding and apoptosis induction were investigated with regard to their potential utility as cytotoxic agents. Molecular modeling methods are used to study the cytotoxic activity of the active compounds by means of molecular and quantum mechanics.