443988-53-2Relevant articles and documents
Synthesis and use of α-silyl-substituted α-hydroxyacetic acids
Bolm, Carsten,Kasyan, Andrey,Heider, Peter,Saladin, Sandra,Drauz, Karlheinz,Guenther, Kurt,Wagner, Christoph
, p. 2265 - 2267 (2007/10/03)
(matrix presented) Rhodium-catalyzed oxygen transfer was used to generate benzyl 2-silyl-2-oxoacetates in good yields. The hydrogenation of these compounds led to chiral α-silyl-substituted α-hydroxyacetic acids. Resolution by means of HPLC using a chiral stationary phase afforded an enantiomerically pure representative of this class of compounds, which was successfully applied as a chiral ligand in an asymmetric aldol-type reaction.