4441-30-9 Usage
Description
3-Morpholinopropanol, also known as 4-(3-Hydroxypropyl)morpholine, is an organic compound that features a morpholine ring with a hydroxypropyl group attached. This structure endows it with unique chemical properties, making it a versatile building block in the synthesis of various compounds.
Uses
Used in Pharmaceutical Industry:
3-Morpholinopropanol is used as a synthetic intermediate for the development of macrocyclic urea compounds. These compounds have potential applications as potent Chk1 inhibitors, which are important in the field of oncology for their role in cell cycle regulation and as targets for cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 4441-30-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,4 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4441-30:
(6*4)+(5*4)+(4*4)+(3*1)+(2*3)+(1*0)=69
69 % 10 = 9
So 4441-30-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H15NO2/c9-5-1-2-8-3-6-10-7-4-8/h9H,1-7H2
4441-30-9Relevant articles and documents
Platinum-Catalyzed, Terminal-Selective C(sp3)-H Oxidation of Aliphatic Amines
Lee, Melissa,Sanford, Melanie S.
supporting information, p. 12796 - 12799 (2015/10/28)
This Communication describes the terminal-selective, Pt-catalyzed C(sp3)-H oxidation of aliphatic amines without the requirement for directing groups. CuCl2 is employed as a stoichiometric oxidant, and the reactions proceed in high yield at Pt loadings as low as 1 mol%. These transformations are conducted in the presence of sulfuric acid, which reacts with the amine substrates in situ to form ammonium salts. We propose that protonation of the amine serves at least three important roles: (i) it renders the substrates soluble in the aqueous reaction medium; (ii) it limits binding of the amine nitrogen to Pt or Cu; and (iii) it electronically deactivates the C-H bonds proximal to the nitrogen center. We demonstrate that this strategy is effective for the terminal-selective C(sp3)-H oxidation of a variety of primary, secondary, and tertiary amines.