4445-43-6Relevant articles and documents
ACLY INHIBITORS AND USES THEREOF
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Paragraph 00842; 00897, (2020/06/01)
The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
ANTIBACTERIAL QUINAZOLINE-4(3H)-ONE DERIVATIVES
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Page/Page column 99, (2015/12/31)
The invention relates to antibacterial compounds of formula I, wherein R1 is H or halogen; R2 is the group M; R3 is H or halogen; M is MA or MB wherein A is a bond or C≡C; R1A is H or halo
Biaryl substituted alkylboronate esters as thrombin inhibitors
Quan,Wityak,Dominguez,Duncia,Kettner,Ellis,Liauw,Park,Santella,Knabb,Thoolen,Weber,Wexler
, p. 1595 - 1600 (2007/10/03)
Thrombin is a serine protease that plays an important role in the blood coagulation cascade, and is a target enzyme for new therapeutic agents. Ac- (D)-Phe-Pro-boroArg-OH (DuP 714) was found to be a highly effective thrombin inhibitor. In order to reduce the peptidic nature of DuP 714, we have designed a series of novel biaryl substituted alkylboronate esters as potent thrombin inhibitors. The most potent compounds have subnanomolar affinity for thrombin.