446276-09-1

Basic information

• Product Name: 1-(4-ACETYLPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE
• Synonyms: 1-(4-ACETYLPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE
• CAS NO: 446276-09-1
• Molecular Formula: C13H9N3O3
• Molecular Weight: 255.23
• Mol File: 446276-09-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 270-272°C
• Appearance: /
• CAS DataBase Reference: 1-(4-ACETYLPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ACETYLPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE(446276-09-1)
• EPA Substance Registry System: 1-(4-ACETYLPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBONITRILE(446276-09-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 446276-09-1(Hazardous Substances Data)

Usage

Description

1-(4-Acetylphenyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile, commonly known as thiamphenicol, is a broad-spectrum antibiotic that belongs to the class of oxazolidinones. It is effective against a wide range of bacterial infections by inhibiting protein synthesis in bacteria. Thiamphenicol is recognized by the World Health Organization as a critically important antimicrobial, and its use is subject to careful management to prevent antibiotic resistance.

Uses

Used in Veterinary Medicine:
Thiamphenicol is used as a therapeutic agent for treating various bacterial infections in animals, particularly those affecting the respiratory, urinary, and skin systems. Its broad-spectrum action makes it a valuable tool in veterinary medicine for managing a range of bacterial conditions.
Used in Human Medicine:
Although its use in humans is limited due to the risk of serious side effects such as bone marrow suppression and aplastic anemia, thiamphenicol is employed as an antibiotic for treating certain types of bacterial meningitis and other severe infections. Its application in human medicine is carefully regulated to minimize the potential for adverse effects and to preserve its effectiveness against resistant bacteria.
Used in Antimicrobial Resistance Management:
Thiamphenicol is recognized as a critically important antimicrobial by the World Health Organization. As such, it is used as a tool in the strategic management of antibiotic resistance. Its use is closely monitored and regulated to ensure that it remains an effective treatment option for serious bacterial infections, particularly in cases where other antibiotics may be less effective or unavailable.