446302-83-6

Basic information

• Product Name: 1-Benzyl-3-phenylpiperidin-4-one
• Synonyms: 1-Benzyl-3-phenylpiperidin-4-one;4-Piperidinone, 3-phenyl-1-(phenylMethyl)-
• CAS NO: 446302-83-6
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.35
• Mol File: 446302-83-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 56-58℃
• Boiling Point: 418.8 °C at 760 mmHg
• Flash Point: 194.4 °C
• Appearance: /
• Density: 1.121
• Vapor Pressure: 3.2E-07mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Benzyl-3-phenylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-phenylpiperidin-4-one(446302-83-6)
• EPA Substance Registry System: 1-Benzyl-3-phenylpiperidin-4-one(446302-83-6)

Safety Data

• Hazardous Substances Data: 446302-83-6(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-phenylpiperidin-4-one, also known as BZP, is a chemical compound that belongs to the piperidine class. It is a psychoactive drug with stimulant effects that is often used as a recreational drug. BZP is structurally similar to amphetamine and acts as a serotonin-norepinephrine-dopamine reuptake inhibitor. It is known to produce effects such as increased energy, alertness, and euphoria, but can also cause adverse effects such as nausea, anxiety, and insomnia. BZP and its analogues have been banned in many countries due to their potential for abuse and adverse health effects, and are classified as controlled substances in some jurisdictions.

InChI:InChI=1/C18H19NO/c20-18-11-12-19(13-15-7-3-1-4-8-15)14-17(18)16-9-5-2-6-10-16/h1-10,17H,11-14H2

Upstream product

• 907997-09-5 2-phenyl-1,4-pentadien-3-one 
• 100-46-9 benzylamine 
• 632352-55-7 ethyl 1-benzyl-4-hydroxy-5-phenyl-1,2,5,6-tetrahydro-3-pyridine carboxylate 
• 632352-54-6 3-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-2-phenyl-propionic acid ethy ester 
• 1384264-55-4 C₂₁H₂₃NO₃ 
• 100-39-0 benzyl bromide 
• 98-86-2 acetophenone 
• 76886-55-0 Acetophenone 2,4,6-triisopropylbenzenesulphonyl hydrazone 
• 907997-19-7 2-phenyl-1,4-pentadien-3-ol 

Downstream Products

• 76041-09-3 3-phenyl-4-piperidone 
• 1215036-17-1 rac-1-benzyl-4-(hydroxyimino)-3-phenylpiperidine 
• 632352-56-8 (±)-tert-butyl 4-oxo-3-phenylpiperidine-1-carboxylate 
• 880135-38-6 tert-butyl (3R,4S)-4-amino-3-phenylpiperidine-1-carboxylate 

Relevant articles and documents

Development of κ opioid receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: Structure-activity relationship study of matrine type alkaloids

A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety of phenyl substituents and evaluated for their anti

Synthesis of 3-phenyl-4-piperidones from acetophenone by shapiro and azamichael reactions and their further derivatization

The Shapiro reaction of acetophenone is the key in a convenient three-step access to a divinyl ketone which is further transformed by double aza-Michael reactions with primary amines into N-substituted 3-phenyl-4-piperidones. In the case of N-benzyl and N