447408-28-8Relevant articles and documents
Evaluation of diene hierarchies for Diels-Alder reactions en route to xestocyclamine A: Elaboration of an ansa bridge by B-alkyl Suzuki macrocyclization
Gagnon, Alexandre,Danishefsky, Samuel J.
, p. 1581 - 1584 (2007/10/03)
A double Michael addition of amine 2 to 1 was a key reaction in the synthesis of the isoquinuclidine core 4 of xestocyclamine A, a protein kinase C inhibitor. The first ansa bridge was formed efficiently by a B-alkyl Suzuki coupling in 3. TBDPS = tert-but