449170-24-5

Basic information

• Product Name: N-(4-Chloro-2-methoxy-5-methyl-phenyl)-2,2-dimethyl-propionamide
• Synonyms: N-(4-Chloro-2-methoxy-5-methyl-phenyl)-2,2-dimethyl-propionamide
• CAS NO: 449170-24-5
• Molecular Weight: 255.744
• Mol File: 449170-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-Chloro-2-methoxy-5-methyl-phenyl)-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chloro-2-methoxy-5-methyl-phenyl)-2,2-dimethyl-propionamide(449170-24-5)
• EPA Substance Registry System: N-(4-Chloro-2-methoxy-5-methyl-phenyl)-2,2-dimethyl-propionamide(449170-24-5)

Safety Data

• Hazardous Substances Data: 449170-24-5(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 6376-14-3 2-methoxy-5-methyl-4-chloroaniline 

Downstream Products

• 106746-92-3 2-(chloromethyl)-4-chloro-6-methoxy-3-methylaniline hydrochloride 

Relevant articles and documents

Substituted 2-anilines as Potential Inhibitors of H+/K+ ATPase

A series of substituted 2-anilines were synthesized as potential inhibitors of the acid secretory enzyme H+/K+ ATPase.Substitutions on the aniline nitrogen atom resulted in potent enzyme inhibition in vitro but weak activity in gastric fistula dogs.Electron-donating substituents on the aniline ring enhanced in vitro and in vivo potency relative to the unubstituted analogue.The potency showed a correlation to the calculated pKa of the aniline nitrogen atom.Substitutions on the aniline and benzimidazole rings did not further enhance potency.Di- and trisubstituted aniline derivatives were potent inhibitors of the enzyme system.The preferred combination of substituents were a methoxy group on the benzimidazole ring and a single alkyl group on the aniline ring.One such compound, 76, was an effective inhibitor of acid secretion in the dog and was selected for further pharmacological study.