449171-15-7Relevant articles and documents
PRODRUGS OF D-ISOGLUTAMYL-[D/L]-TRYPTOPHAN
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Page/Page column 34, (2012/10/18)
Provided are carboxylic ester derivatives of formula (I), methods of preparing them, and methods for using them. These compounds are prodrugs of D-isoglutamyl-[D/L]-tryptophan. The in vitro bioconversion of some of the prodrugs to the parent drug D-isoglutamyl-D-tryptophan (or thymodepressin) was tested in human hepatocytes and in human blood. In vivo pharmacokinetic studies following oral administration of some of the prodrugs to rats are also reported.