450370-35-1

Basic information

• Product Name: (S)-N-(1-phenylethyl)-4-chlorobutyrylamide
• Synonyms: (S)-N-(1-phenylethyl)-4-chlorobutyrylamide
• CAS NO: 450370-35-1
• Molecular Weight: 225.718
• Mol File: 450370-35-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-N-(1-phenylethyl)-4-chlorobutyrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(1-phenylethyl)-4-chlorobutyrylamide(450370-35-1)
• EPA Substance Registry System: (S)-N-(1-phenylethyl)-4-chlorobutyrylamide(450370-35-1)

Safety Data

• Hazardous Substances Data: 450370-35-1(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 1239906-38-7 C₄H₇BrClNO₂ 

Downstream Products

• 106137-78-4 (S)-N-(1'-phenylethyl)-2-pyrrolidinone 
• 106058-72-4 1-<1(S)-phenylethyl>pyrrolidine-2-thione 
• 200397-90-6 1-<1'-(S)-phenylethyl>-2-(ethoxycarbonylmethylidene)pyrrolidine 
• 107784-09-8 [(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester 

Relevant articles and documents

Umpolung Amide Synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen AS a terminal oxidant

Umpolung Amide Synthesis (UmAS) provides direct access to amides from an α-bromo nitroalkane and an amine. Based on its mechanistic bifurcation after convergent C-N bond formation, depending on the absence or presence of oxygen, UmAS using substoichiometric N-iodosuccinimide (NIS) under aerobic conditions has been developed. In combination with the enantioselective preparation of α-bromo nitroalkane donors, this protocol realizes the goal of enantioselective α-amino amide and peptide synthesis based solely on catalytic methods.

ASYMMETRIC SYNTHESIS OF 1-METHYL-2-(2-HYDROXYETHYL)PYRROLIDINE

An asymmetric synthesis of 1-methyl-2-(2-hydroxyethyl)pyrrolidine based on optically active 1-phenylethylamine is described.