450412-29-0

Basic information

• Product Name: 2-IODO-3-BROMOFLUOROBENZENE
• Synonyms: 2-IODO-3-BROMOFLUOROBENZENE;1-BROMO-3-FLUORO-2-IODOBENZENE;2-Bromo-6-fluoroiodobenzene 99%;2-Bromo-6-fluoroiodobenzene99%;2-Iodo-3-Bromofluorobenzen
• CAS NO: 450412-29-0
• Molecular Formula: C₆H₃BrFI
• Molecular Weight: 300.89
• Mol File: 450412-29-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 249℃
• Flash Point: 104℃
• Appearance: /
• Density: 2.281
• Vapor Pressure: 0.0379mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-IODO-3-BROMOFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-3-BROMOFLUOROBENZENE(450412-29-0)
• EPA Substance Registry System: 2-IODO-3-BROMOFLUOROBENZENE(450412-29-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 450412-29-0(Hazardous Substances Data)

Usage

Physical Form

Yellow Solid or Liquid

Uses

1-Bromo-3-fluoro-2-iodobenzene is a useful research chemical.

InChI:InChI=1/C6H3BrFI/c7-4-2-1-3-5(8)6(4)9/h1-3H

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 65896-11-9 2-bromo-6-fluoroaniline 

Downstream Products

• 1142923-83-8 C₂₀H₂₃BrFNO₂ 
• 1342879-18-8 1-fluoro-5-phenyl-5H-dibenzophosphole 
• 1300117-98-9 (6-(fluoro)biphenyl-2,2'-diyl)bisdiphenylphosphine 
• 1404115-53-2 C₈H₅BrF₃NO 
• 1404115-55-4 C₁₃H₁₅BrF₃NO₂ 
• 1404115-77-0 C₁₃H₁₂F₃N₃O 
• 1404115-51-0 C₁₀H₈BrF₃O₂ 
• 936618-92-7 2-(3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 50548-45-3 1-bromodibenzo[b,d]furan 
• 162607-19-4 dibenzo[b,d]furan-1-yl-boronic acid 

Relevant articles and documents

Photocyclodehydrofluorination

Mallory-type photocyclization involves a series of photoreactions of stilbenes, o-terphenyls and related derivatives, which undergo intramolecular cyclization via dihydrophenanthrene intermediates. In typical Mallory photocyclizations, oxidants are usually needed to produce the final phenanthrene-containing product. In the research described here, appropriately fluorinated stilbenes and o-terphenyls undergo ring closure and HF is eliminated. This photocyclodehydrofluorination (PCDHF) reaction is very useful to produce a wide range of selectively fluorinated polynuclear aromatic hydrocarbons that possess a phenanthrene (or heterocyclic analogue of phenanthrene) substructure. These fluorinated products are of great interest in various aspects of the materials science.

Ring opening of aziridines with ortho-bromophenyl metal reagents: synthesis of 2-substituted indolines

Stabilized ortho-bromo phenyllithium reagents, generated via lithium-halogen exchange of aryl iodides, undergo regioselective ring opening of mono-substituted N-Boc, N-Cbz, and N-tosyl-protected aziridines in good to excellent yields. The resulting ortho-

Generation and suppression of 3-/4-functionalized benzynes using zinc ate base (TMP-Zn-ate): New approaches to multisubstituted benzenes

We present full details of our new methods for preparing functionalized benzynes with lithium di-alkyl(2,2,6,6-tetramethylpiperidino)zincate (R 2Zn(TMP)Li) through deprotonative zincation as a key reaction. In this system, by choosing appropriate ligands for the zincate, either regioselective zincation of functionalized haloaromatics or the generation of substituted benzynes can be controlled in good yields with excellent chemoselectivity, using the same substrate. Zincation with tBu 2Zn(TMP)Li followed by electrophilic trapping or zincation with Me2Zn(TMP)Li followed by nucleophilic or diene trapping is shown to be a powerful tool for the chemoselective preparation of 1,2,3-/1,2,4- trisubstituted benzene derivatives. These methods offer far greater generality than previous methods for the synthesis of multifunctionalized benzenes. Computational/theoretical studies of the reaction mechanism of this unique benzyne formation indicated that preferential coordination of the dialkylzinc moiety of zincate to halogen is the reason for the reduced activation energy of the elimination, that is, for the formation of the benzyne. The role of the ligands on Zn in accelerating/decelerating the elimination is also discussed.