451455-95-1

Basic information

• Product Name: Phosphonic acid, [(3,4-difluorophenyl)methyl]-, diethyl ester
• CAS NO: 451455-95-1
• Molecular Formula: C11H15F2O3P
• Molecular Weight: 264.209
• Mol File: 451455-95-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(3,4-difluorophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(3,4-difluorophenyl)methyl]-, diethyl ester(451455-95-1)
• EPA Substance Registry System: Phosphonic acid, [(3,4-difluorophenyl)methyl]-, diethyl ester(451455-95-1)

Safety Data

• Hazardous Substances Data: 451455-95-1(Hazardous Substances Data)

Upstream product

• 85118-01-0 alpha-bromo-3,4-difluorotoluene 
• 122-52-1 triethyl phosphite 

Downstream Products

• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 1006376-61-9 (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester 
• 1332895-51-8 {1-(3,4-difluorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid 
• 1332895-47-2 [1-(3,4-difluorophenyl)-4-(hydroxyamino)-4-oxobutyl]phosphonic acid 
• 1332895-44-9 {4-[(benzyloxy)(methyl)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonic acid 
• 1332895-40-5 dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate 
• 1332895-35-8 diethyl {4-[(benzyloxy)(methyl)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate 
• 1332895-33-6 diethyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate 
• 1332895-30-3 4-(diethoxyphosphoryl)-4-(3,4-difluorophenyl)butanoic acid 
• 1332895-27-8 diethyl [1-(3,4-difluorophenyl)-4-oxobutyl]phosphonate 
• 1332895-24-5 diethyl [1-(3,4-difluorophenyl)-3-(1,3-dioxolan-2-yl)propyl]phosphonate 
• 902526-72-1 2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-(3,4-difluoro-phenyl)-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester 
• 902526-69-6 2,2-dimethyl-propionic acid [3-(benzyloxy-formyl-amino)-1-(3,4-difluoro-phenyl)-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester 

Relevant articles and documents

Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes

The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI50) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the ability to induce apoptosis following drug treatment by the most potent agents in the series, e.g., 5dy and 5jy, an observation further reinforced by Annexin V-FITC analysis and fluorescence microscopy.

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

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