45172-44-9

Basic information

• Product Name: BOC-L-SELENOMETHIONINE
• Synonyms: BOC-L-SELENOMETHIONINE;BOC-SELENO-L-METHIONINE;(S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylselanyl)butanoic acid
• CAS NO: 45172-44-9
• Molecular Formula: C₁₀H₁₉NO₄Se
• Molecular Weight: 296.22
• Product Categories: Seleno Amino Acid;amino acids
• Mol File: 45172-44-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-L-SELENOMETHIONINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-SELENOMETHIONINE(45172-44-9)
• EPA Substance Registry System: BOC-L-SELENOMETHIONINE(45172-44-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 45172-44-9(Hazardous Substances Data)

Upstream product

• 109276-72-4 L-benzyl N-t-butoxycarbonylselenomethioninate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3211-76-5 Seleno-L-methionine 
• 30924-93-7 Boc-Glu-OBn 
• 109276-71-3 (S)-2-tert-Butoxycarbonylamino-pentanedioic acid 1-benzyl ester 5-(2-thioxo-2H-pyridin-1-yl) ester 
• 95656-97-6 benzyl 4-bromo-2-<(tert-butyloxy)carbonylamino>butanoate 

Downstream Products

• 3211-76-5 Seleno-L-methionine 

Relevant articles and documents

Preparation method and application of glycyrrhetinic acid, ferulic acid and selenomethionine ternary compound

The invention discloses a preparation method and an application of a novel glycyrrhetinic acid derivative shown in a figure 1. Ferulic acid methylester is introduced in the 30-position carboxyl position of glycyrrhetinic acid; NO.3-position hydroxyl of glycyrrhetinic acid is subjected to structure modification, and Boc-L-selenomethionine is introduced; then, after Boc protection is removed, the glycyrrhetinic acid derivative in a form of hydrochloride is obtained. A better inhibition function of the glycyrrhetinic acid derivative on two breast cancer MCF-7 and MBA-MD-231 cells is measured, and the glycyrrhetinic acid derivative can be taken as an anticancer drug for further research and development.

Synthesis and biological evaluation of novel curcuminoid derivatives

Curcuminoids have been reported to possess multiple bioactivities, such as antioxidant, anticancer and anti-inflammatory properties. Three novel series of curcuminoid derivatives (11a-h, 15a-h and 19a-d) with enhanced bioactivity have been synthesized. Among the synthesized compounds, 11b exhibited the most significant activity with an MIC of 0.5 μ M /mL against selected medically important Gram-positive cocci (S aureus and S viridans) and Gram-negative bacilli (E. coli and E. cloacae). The derivatives exhibited remarkable results in an antioxidant test with an IC50 2.4- to 9.3-folder smaller than curcuminoids. With respect to antiproliferative activity against Hep-G2, LX-2, SMMC7221 and MDA-MB-231, the derivatives exhibited an effect stronger than curcuminoids with an IC50 ranging from 0.18 to 4.25 μ M.

CONCISE SYNTHESES OF L-SELENOMETHIONINE AND OF L-SELENOCYSTINE USING RADICAL CHAIN REACTIONS

L-Selenomethionine and L-selenocystine were prepared in high overall yields from protected L-glutamic and L-aspartic acid derivatives respectively.Irradiation of the mixed anhydrides (esters) derived from 4 (e.g. 15) in the presence of dimethyldiselenide provided the protected L-selenomethionine 16 directly.We have shown that triselenocyanide Se3(CN)2 can serve as an efficient selenocyanating agent for radicals; the selenocyanide group is a good precursor for the diselenide moiety of L-selenocystine.