4518-70-1

Basic information

• Product Name: Methyl corosolate
• Synonyms: Methyl corosolate;(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic acid methyl ester;(2alpha,3beta)-2,3-Dihydroxy-urs-12-en-28-oic acid methyl ester
• CAS NO: 4518-70-1
• Molecular Formula: C₃₁H₅₀O₄
• Molecular Weight: 486.73
• Product Categories: Pentacyclic Triterpenes;Miscellaneous Natural Products
• Mol File: 4518-70-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 541.892 °C at 760 mmHg
• Flash Point: 163.088 °C
• Appearance: /
• Density: 1.112 g/cm³
• CAS DataBase Reference: Methyl corosolate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl corosolate(4518-70-1)
• EPA Substance Registry System: Methyl corosolate(4518-70-1)

Safety Data

• Hazardous Substances Data: 4518-70-1(Hazardous Substances Data)

Usage

General Description

Methyl corosolate is a chemical compound that belongs to the corosolic acid family, which is commonly found in the leaves of the banaba plant. It is often used for its potential medicinal properties, such as its ability to lower blood sugar levels and improve insulin sensitivity. Due to its potential antidiabetic effects, methyl corosolate has gained attention as a natural remedy for managing diabetes and metabolic disorders. Research suggests that it may help lower the risk of developing diabetes and improve glucose metabolism. Moreover, it may also have anti-inflammatory and antioxidant properties, making it a potential candidate for further biomedical research. Despite its potential health benefits and therapeutic uses, more studies are needed to fully understand the efficacy and safety of methyl corosolate.

Upstream product

• 186581-53-3 diazomethane 
• 4547-24-4 corosolic acid 
• 1721-58-0 methyl 3-oxooleanolate 
• 14810-68-5 3-Acetoxy-ursadien-(2.12)-saeure-⁽²⁸⁾-methylester 
• 35011-95-1 (1S,2R,4aS,6aS,6bR,8aR,11R,12aR,12bR,14bS)-11-Acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid methyl ester 
• 74-88-4 methyl iodide 
• 989-72-0 methyl ursonate 
• 14087-64-0 methyl 2α,3β-diacetoxyurs-12-en-28-oate 
• 915-32-2 methyl (3β)-3-hydroxyurs-12-en-28-oate 
• 919092-94-7 methyl 2a-hydroxy-3-oxours-12-en-28-oate 

Downstream Products

• 4547-24-4 corosolic acid 
• 4547-28-8 2α,3β,28-trihydroxyurs-12-ene 

Relevant articles and documents

Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs

The terpenoidal oxaliplatin derivatives (6) and (12) were newly synthesized using 2β,3α-dihydroxy-11-oxo-18β-olean-12-ene-30-oic acid (1) and 2α,2β-dihydroxy-18β-ursan-12-ene-28-oic acid (7) as starting materials. The synthesized compounds were evaluated for their cytotoxicity and antioxidant activities and were compared to Oxaliplatin and vitamin C as positive controls. Some of the compounds exhibited better cytotoxicity and antioxidant activities than the reference controls. The detailed synthesis, spectroscopic data, toxicity (LD50) and pharmacological screening for the synthesized compounds were reported.

COMPOUNDS FOR REDUCING GLUCOCORTICOIDS, AND METHODS OF TREATMENT THEREOF

A method for reducing glucocorticoids in an animal in need thereof comprising the use of compounds of the formula (I), wherein the definitions for R', R1-R11 and n are as disclosed in the description. The compounds of formula (I) are for the treatment or prevention of a glucocorticoid-related disorder for maintaining bone density, maintaining and improving the immune system, treating Cushing' s syndrome, treating obesity, improving reproduction efficiency, treating metabolic disorder, treating hypertension, treating hyperglycemia, treating insulin resistance, treating type 2 diabetes, and/or aiding in cancer and immune therapies

NOVEL STRUCTURAL ANALOGS OF COROSOLIC ACID HAVING ANTI-DIABETIC AND ANTI-INFLAMMATORY PROPERTIES

This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are as indicated below in each of said analogs: 1. R1 = COCH3, R2/sub