452-08-4

Basic information

• Product Name: 2-Bromo-4-fluoroanisole
• Synonyms: 1-BROMO-3-FLUORO-6-METHOXYBENZENE;2-BROMO-4-FLUOROANISOLE;2-BROMO-4-FLUORO-METHOXYBENZENE;2-BROMO-4-FLUORO-1-METHOXYBENZENE;2-Bromo-4-FlouroAnisole;2-Bromo-4-fluoroanisole 97%;2-Bromo-4-fluoroanisole97%;2-Bromo-4-fluoroanisole,98%
• CAS NO: 452-08-4
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• EINECS: -0
• Product Categories: Fluorobenzene;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 452-08-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 89 °C1 mm Hg(lit.)
• Flash Point: 209 °F
• Appearance: Clear slightly yellow liquid
• Density: 1.581 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.545(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• BRN: 2358880
• CAS DataBase Reference: 2-Bromo-4-fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluoroanisole(452-08-4)
• EPA Substance Registry System: 2-Bromo-4-fluoroanisole(452-08-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 452-08-4(Hazardous Substances Data)

Usage

Description

2-Bromo-4-fluoroanisole is an organic compound characterized by its clear, slightly yellow liquid appearance. It is a derivative of anisole, featuring a bromine atom at the 2nd position and a fluorine atom at the 4th position on the aromatic ring.

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-fluoroanisole is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block for the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
2-Bromo-4-fluoroanisole is used as a reagent in the synthesis of (5-fluoro-2-methoxyphenyl)methanol, which is an important compound in the chemical industry. This synthesis demonstrates the utility of 2-bromo-4-fluoroanisole in creating complex organic molecules for various applications.

InChI:InChI=1/C7H6BrFO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,1H3

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 1978-39-8 5-fluoro-2-methoxy-aniline 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 74-88-4 methyl iodide 
• 394-04-7 5-fluoro-2-methoxybenzoic acid 
• 578-57-4 2-bromoanisole 

Downstream Products

• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 72955-97-6 5-fluoro-2-methoxy phenol 
• 183280-22-0 (5-Fluoro-2-methoxy-phenyl)-(4-trifluoromethyl-phenyl)-methanone 
• 189628-38-4 5-fluoro-2-methoxybenzonitrile 
• 178977-00-9 4-Fluoro-1-methoxy-2-(2-methyl-allyl)-benzene 
• 223778-71-0 ethyl 3-(5'-fluoro-2'-methoxyphenyl)-2-propenoate 
• 630103-11-6 4-fluoro-2,2'-dimethoxydiphenyl ether 
• 791068-92-3 5-fluoro-2-methoxy-1,1'-biphenyl 
• 71313-97-8 2-(5-fluoro-2-methoxyphenyl)propan-2-ol 
• 920508-14-1 (5-fluoro-2-methoxy-phenyl)-indan-1-yl-methanone 
• 920508-17-4 (5'-fluoro-4,2'-dimethoxy-biphenyl-3-yl)-indan-1-yl-methanone 
• 920508-18-5 (5'-fluoro-4-hydroxy-2'-methoxy-biphenyl-3-yl)-indan-1-yl-methanone 
• 920508-19-6 (5'-fluoro-4,2'-dihydroxy-biphenyl-3-yl)-indan-1-yl-methanone 
• 920508-21-0 Br₆₂ 

Relevant articles and documents

Fluorinations of unsymmetrical diaryliodonium salts containing: Ortho -sidearms; Influence of sidearm on selectivity

Activated aromatics were reacted with two different fluoroidoane reagents 1 and 2 in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane 1 the unsymmetrical diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alcohol sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane 2. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

Study on the electronic effect on coordinating donors in heptacoordinate trichlorogermanes

Trichloro[tris(2,5-dimethoxyphenyl)methyl]germane (1a), trichloro[tris(3-fluoro-6-methoxyphenyl)methyl]germane (1b), and trichloro[tris(2-methoxy-5-trifluoromethylphenyl)methyl]germane (1c) were synthesized. X-ray crystallographic analyses of 1a-c revealed their heptacoordinate geometries around the germanium atoms. The interatomic distances between the oxygen atoms and the central germanium atoms in the crystalline state were not significantly affected by change of functional groups on the benzene rings, while the optimized structures by theoretical calculations and Atoms in Molecules (AIM) analysis indicated linear relationship between the donating ability of functional groups and the O?Ge interatomic interactions.