452-62-0 Usage
Description
3-Bromo-4-fluorotoluene is an organic compound that features a bromine atom at the 3rd position and a fluorine atom at the 4th position on a toluene molecule. It is a valuable intermediate in the synthesis of various organic compounds and pharmaceuticals due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
3-Bromo-4-fluorotoluene is used as a starting reagent for the synthesis of [4-fluoro-3-(trimethylsilyl)benzyl]guanidine, which is a key intermediate in the production of pharmaceuticals. Its unique structure allows for the formation of new chemical bonds and the creation of novel drug candidates.
Used in Organic Synthesis:
3-Bromo-4-fluorotoluene is used as a benzyne precursor in the synthesis of 6-methyl-1,2,3,4-tetrahydro-2,3-(benzylidenedioxy)-1,4-ethenonapthalene. Benzyne is an important intermediate in organic synthesis, and its formation from 3-bromo-4-fluorotoluene allows for the creation of complex organic molecules with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 452-62-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 452-62:
(5*4)+(4*5)+(3*2)+(2*6)+(1*2)=60
60 % 10 = 0
So 452-62-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BrF/c1-5-2-3-7(9)6(8)4-5/h2-4H,1H3
452-62-0Relevant articles and documents
Process for the preparation of fluoroaromatic compounds substituted in the o-position
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, (2008/06/13)
Ortho-substituted fluoroaromatic compounds are prepared by reaction of corresponding anilines, which are substituted in the o-position, with alkyl nitrites in the presence of alcohols and/or ethers and in the presence of boron trifluoride or boric acid esters and hydrogen fluoride, and by isolation and decomposition of the diazonium tetrafluoborate produced.
