452056-98-3Relevant articles and documents
Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors
Laufer, Stefan,Hauser, Dominik,Stegmiller, Thomas,Bracht, Claudia,Ruff, Kathrin,Schattel, Verena,Albrecht, Wolfgang,Koch, Pierre
scheme or table, p. 6671 - 6675 (2010/12/19)
The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole seri
2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS
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Page/Page column 29, (2008/06/13)
The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the