4525-48-8

Basic information

• Product Name: 2-Methylbenzyldimethylamine
• Synonyms: 2-Methylbenzyldimethylamine;2,N,N-Trimethylbenzenemethanamine;N,N,2-Trimethylbenzylamine;BenzeneMethanaMine, N,N,2-triMethyl-
• CAS NO: 4525-48-8
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.2328
• Mol File: 4525-48-8.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methylbenzyldimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylbenzyldimethylamine(4525-48-8)
• EPA Substance Registry System: 2-Methylbenzyldimethylamine(4525-48-8)

Safety Data

• Hazardous Substances Data: 4525-48-8(Hazardous Substances Data)

Usage

General Description

2-Methylbenzyldimethylamine, also known as N,N-dimethyl-2-tolylamine, is a chemical compound that belongs to the amine class of organic compounds. It is a tertiary amine, which means it has three alkyl groups bonded to the nitrogen atom. It is commonly used as a Lewis base in organic synthesis, as a curing agent for epoxy resins, and as an intermediate for pharmaceuticals, dyes, and other organic compounds. It is a colorless to yellow liquid with a strong, ammonia-like odor. It is important to handle 2-Methylbenzyldimethylamine with care, as it can be harmful if inhaled, ingested, or comes into contact with the skin.

Upstream product

• 100-97-0 hexamethylenetetramine 
• 89-92-9 2-methylbenzyl bromide 
• 4525-46-6 benzyltrimethylammonium iodide 
• 51180-47-3 Dimethyl-((E)-penta-2,4-dienyl)-prop-2-ynyl-ammonium; bromide 
• 30481-22-2 Allyl-((Z)-3-chloro-penta-2,4-dienyl)-dimethyl-ammonium; bromide 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 68971-87-9 (2-tolyl)tributyltin 
• 72443-52-8 Benzyldimethyl<(trimethylsilyl)methyl>ammonium bromide 
• 54848-55-4 1,1,3,3-Tetramethyl-1,2,3,4-tetrahydrobenzo--1,3-azoniasiline Iodide 
• 72443-53-9 Benzyldimethyl[(dimethylphenylsilyl)methyl]ammonium bromide 
• 72443-54-0 Benzyldimethyl<(methyldiphenylsilyl)methyl>ammonium bromide 
• 72443-55-1 Benzyldimethyl<(triphenylsilyl)methyl>ammonium chloride 
• 134835-16-8 Cyanomethyl-dimethyl-(2-methyl-benzyl)-ammonium; chloride 
• 134835-18-0 Carbamoylmethyl-dimethyl-(2-methyl-benzyl)-ammonium; chloride 

Downstream Products

• 78501-08-3 dimethyl-<(o-methylbenzyl)phenacyl>ammonium bromide 
• 117867-97-7 N,N,N-trimethyl-1-(o-tolyl)methanaminium iodide 
• 97196-59-3 Dimethyl-butyl-<2-methyl-benzyl>-ammonium-iodid 
• 41839-73-0 benzyl>dimethylamine 
• 72443-62-0 N,N-Dimethyl-2-<(triphenylsilyl)methyl>benzylamine 
• 7647-48-5 2-Phenethyl-N,N-dimethyl-benzylamin 
• 20176-06-1 1-methyl-2-cyanonaphthalene 
• 24393-48-4 ethyl trans-2-methylcinnamate 
• 83781-47-9 trimethyl<2-<(trimethylsilyl)methyl>benzyl>ammonium iodide 
• 83781-51-5 benzyl>dimethylamine 
• 83781-52-6 benzyl>dimethylamine 
• 83781-53-7 benzyl>dimethylamine 
• 83781-96-8 benzyl>dimethylamine 
• 73331-50-7 benzyl>trimethylammonium bromide 

Relevant articles and documents

Palladium-Catalyzed Reductive Aminocarbonylation of Benzylammonium Triflates with o-Nitrobenzaldehydes for the Synthesis of 3-Arylquinolin-2(1 H)-ones

A palladium-catalyzed straightforward procedure for the synthesis of 3-arylquinolin-2(1H)-ones has been developed. The synthesis proceeds through a palladium-catalyzed reductive aminocarbonylation reaction of benzylic ammonium triflates with o-nitrobenzaldehydes, and a wide range of 3-arylquinolin-2(1H)-ones was obtained in moderate to good yields with very good functional group compatibility.

Electrochemical Dehydrogenative Imidation of N-Methyl-Substituted Benzylamines with Phthalimides for the Direct Synthesis of Phthalimide-Protected gem-Diamines

A general and green electrochemical dehydrogenative method for the imidation of N-methyl benzylamines with phthalimides with excellent regioselectivities is reported for the first time. This operationally simple method offers a valuable tool to obtain str

Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources

A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation.