452972-12-2 Usage
General Description
2-Bromo-3-pyridineboronic acid pinacol ester is a chemical compound that is often used in organic synthesis and medicinal chemistry for its unique reactivity and ability to form carbon-carbon and carbon-heteroatom bonds. It is a boronic acid ester derivative that contains a bromine atom and a pyridine ring, making it a versatile building block in the creation of various pharmaceuticals, agrochemicals, and materials science applications. The pinacol ester functional group increases the compound's stability and enables its use in challenging reaction conditions, making it a valuable tool for chemists and researchers in the field.
Check Digit Verification of cas no
The CAS Registry Mumber 452972-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,9,7 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 452972-12:
(8*4)+(7*5)+(6*2)+(5*9)+(4*7)+(3*2)+(2*1)+(1*2)=162
162 % 10 = 2
So 452972-12-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H15BBrNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-14-9(8)13/h5-7H,1-4H3
452972-12-2Relevant articles and documents
Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters
Bouillon, Alexandre,Lancelot, Jean-Charles,Collot, Valerie,Bovy, Philippe R.,Rault, Sylvain
, p. 3323 - 3328 (2007/10/03)
This paper describes a general method for the synthesis and the isolation of novel 2,4, or 5-halopyridin-3-yl-boronic acids and esters 4, 7, 10, 13, 15. These compounds are prepared taking into account a regioselective halogen-metal exchange using nBuLi or a regioselective ortho-lithiation using lithium diisopropylamide and subsequent quenching with triisopropylborate starting from appropriate mono or dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pb-catalyzed coupling with a range of arylhalides and authorize a strategy to produce new pyridines libraries.
