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455-15-2

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455-15-2 Usage

Description

4-Fluorophenyl methyl sulfone is an organic compound characterized by its white solid appearance. It is a derivative of phenyl methyl sulfone with a fluorine atom substitution at the 4th position, which imparts unique chemical properties to the molecule.

Uses

Used in Pharmaceutical Industry:
4-Fluorophenyl methyl sulfone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
1. Preparation of Substituted Indazole Amides:
In the pharmaceutical industry, 4-Fluorophenyl methyl sulfone is used as a starting material for the preparation of substituted indazole amides. These compounds serve as glucokinase activators, which play a crucial role in regulating blood glucose levels and have potential applications in the treatment of type 2 diabetes.
2. Synthesis of 4-(4′-Trifluoromethoxyphenoxy)Phenyl Methyl Sulfone:
Another application of 4-Fluorophenyl methyl sulfone in the pharmaceutical industry is its use in the preparation of 4-(4′-trifluoromethoxyphenoxy)phenyl methyl sulfone. 4-FLUOROPHENYL METHYL SULFONE has potential applications in the development of new drugs targeting various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 455-15-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 455-15:
(5*4)+(4*5)+(3*5)+(2*1)+(1*5)=62
62 % 10 = 2
So 455-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3

455-15-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (A12863)  4-Fluorophenyl methyl sulfone, 98%   

  • 455-15-2

  • 5g

  • 685.0CNY

  • Detail
  • Alfa Aesar

  • (A12863)  4-Fluorophenyl methyl sulfone, 98%   

  • 455-15-2

  • 25g

  • 3209.0CNY

  • Detail
  • Alfa Aesar

  • (A12863)  4-Fluorophenyl methyl sulfone, 98%   

  • 455-15-2

  • 100g

  • 10264.0CNY

  • Detail
  • Aldrich

  • (184330)  4-Fluorophenylmethylsulfone  97%

  • 455-15-2

  • 184330-5G

  • 815.49CNY

  • Detail

455-15-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-FLUOROPHENYL METHYL SULFONE

1.2 Other means of identification

Product number -
Other names 4-Fluorophenyl methyl sulfone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:455-15-2 SDS

455-15-2Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

Liu, Teng,Yu, Shiwen,Shen, Xiang,Li, Yixian,Liu, Jianjun,Huang, Chao,Cheng, Feixiang

, p. 153 - 160 (2021/10/04)

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

Liu, Kai-Jian,Wang, Zheng,Lu, Ling-Hui,Chen, Jin-Yang,Zeng, Fei,Lin, Ying-Wu,Cao, Zhong,Yu, Xianyong,He, Wei-Min

supporting information, p. 496 - 500 (2021/01/28)

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is

PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF

-

Paragraph 0384; 0388, (2021/04/10)

The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

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