4553-59-7

Basic information

• Product Name: PHENYL-PHENYLAMINO-ACETONITRILE
• Synonyms: PHENYL-PHENYLAMINO-ACETONITRILE;anilino(phenyl)acetonitrile;2-(Phenylamino)-2-phenylacetonitrile;2-Anilino-2-phenylacetonitrile;N,2-Diphenylglycinonitrile;α-(Phenylamino)benzeneacetonitrile;α-Anilinobenzeneacetonitrile;2-phenyl-2-(phenylaMino)acetonitrile
• CAS NO: 4553-59-7
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.26
• Mol File: 4553-59-7.mol
• Article Data: 178

Chemical Properties

• Boiling Point: 369.7°Cat760mmHg
• Flash Point: 177.4°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: PHENYL-PHENYLAMINO-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL-PHENYLAMINO-ACETONITRILE(4553-59-7)
• EPA Substance Registry System: PHENYL-PHENYLAMINO-ACETONITRILE(4553-59-7)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 4553-59-7(Hazardous Substances Data)

Usage

General Description

PHENYL-PHENYLAMINO-ACETONITRILE, also known as 2-phenylbenzylamine or benzylphenylamine, is a chemical compound with the molecular formula C14H12N2. It is a white solid that is commonly used in the synthesis of pharmaceuticals and organic compounds. PHENYL-PHENYLAMINO-ACETONITRILE is a derivative of acetophenone with a phenylamino group attached to the acetonitrile moiety. It is often used as a building block in organic synthesis for the preparation of various compounds, including pharmaceuticals, agrochemicals, and dyes. Additionally, it is also utilized in the production of rubber chemicals and as an intermediate in the manufacture of other organic compounds.

InChI:InChI=1/C14H12N2/c15-11-14(12-7-3-1-4-8-12)16-13-9-5-2-6-10-13/h1-10,14,16H

Upstream product

• 74-90-8 hydrogen cyanide 
• 538-51-2 benzylidene phenylamine 
• 60-29-7 diethyl ether 
• 151-50-8 potassium cyanide 
• 142-04-1 aniline hydrochloride 
• 100-52-7 benzaldehyde 
• 64-17-5 ethanol 
• 62-53-3 aniline 
• 71-43-2 benzene 
• 532-28-5 (RS)-mandelonitrile 
• 127-09-3 sodium acetate 
• 46887-57-4 1-phenyl-1-phenylaminomethanesulfonic acid 
• 7677-24-9 trimethylsilyl cyanide 
• 86712-42-7 2,3-dianilino-2,3-diphenyl-propionitrile 

Downstream Products

• 52240-29-6 (1-methyl-2-oxo-2-phenyl-ethyl)-malonic acid 
• 861384-66-9 5-cyano-4-methyl-2-oxo-1,5-diphenyl-pyrrolidine-3-carboxylic acid 
• 6932-23-6 1,2,3,4-tetraphenyl-1H-pyrrole 
• 857424-42-1 5-hydroxy-1,2,3-triphenyl-5-styryl-pyrrolidine-2-carbonitrile 
• 86712-42-7 2,3-dianilino-2,3-diphenyl-propionitrile 
• 74-90-8 hydrogen cyanide 
• 2879-66-5 N,N',1,2-tetraphenylethylenediamine 
• 538-51-2 benzylidene phenylamine 
• 62-53-3 aniline 
• 42164-54-5 N-(2-amino-1-phenylethyl)benzenamine 
• 60561-61-7 α-anilino-α-phenylacetamide 
• 51444-33-8 anilino-phenyl-thioacetic acid amide 
• 101350-25-8 (N-acetyl-anilino)-phenyl-acetonitrile 
• 14062-91-0 (N-benzoyl-anilino)-phenyl-acetonitrile 

Relevant articles and documents

Use of polyazaheterocycles in the assembly of new cadmium sulfate frameworks: Synthesis, structure, and properties

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A carbon dioxide-promoted three-component Strecker reaction

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is

Catalytic Strecker reaction: g-C3N4-anchored sulfonic acid organocatalyst for the synthesis of α-aminonitriles

Abstract: Efficient organocatalyst for enantioselective Strecker reaction was synthesized using g-C3N4 sheets (CN). CN-anchored sulfonic acid (CN-Bu-SO3H) was found to be a highly efficient and recoverable organocatalyst f