4561-10-8

Basic information

• Product Name: H-GLU(OBZL)-OBZL HCL
• Synonyms: H-GLU(OBZL)-OBZL HCL;L-GLUTAMIC ACID-ALPHA,GAMMA-DIBENZYL ESTER HYDROCHLORIDE;L-Glutamic acid dibenzyl ester hydrochloride;H-Glu(Obzl)-Obzl hydrochloride;L-GLUTAMIC ACID-A,Y-DIBENZYLESTER HYDROCHLORIDE;L-GLUTAMIC ACID BIS(PHENYLMETHYL) ESTER HYDROCHLORIDE;(2S)-2-aminoglutaric acid dibenzyl ester hydrochloride;bis(phenylmethyl) (2S)-2-azanylpentanedioate hydrochloride
• CAS NO: 4561-10-8
• Molecular Formula: C₁₉H₂₂NO₄*Cl
• Molecular Weight: 363.84
• Mol File: 4561-10-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 102.0 to 106.0 °C
• Boiling Point: 453.5 °C at 760 mmHg
• Flash Point: 165.6 °C
• Appearance: White/Powder
• Vapor Pressure: 2.06E-08mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-GLU(OBZL)-OBZL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLU(OBZL)-OBZL HCL(4561-10-8)
• EPA Substance Registry System: H-GLU(OBZL)-OBZL HCL(4561-10-8)

Safety Data

• RTECS: MA0885000
• Hazardous Substances Data: 4561-10-8(Hazardous Substances Data)

Usage

Description

H-GLU(OBZL)-OBZL HCL, also known as L-Glutamic acid dibenzyl ester hydrochloride oxalate, is an organic compound that serves as an intermediate in pharmaceutical and chemical synthesis. It is a derivative of L-glutamic acid, an essential amino acid, with two benzyl ester groups attached to the carboxylic acid group and a hydrochloride counterion. H-GLU(OBZL)-OBZL HCL is characterized by its potential use in the development of pharmaceuticals and as a research tool in medicinal chemistry.

Uses

Used in Pharmaceutical and Chemical Synthesis:
H-GLU(OBZL)-OBZL HCL is used as an intermediate in the synthesis of various pharmaceuticals and chemical compounds. Its unique structure allows for the formation of new chemical entities with potential therapeutic applications.
Used in Medicine Research:
H-GLU(OBZL)-OBZL HCL is also utilized in medicine research as a tool to study the structure-activity relationships of L-glutamic acid derivatives and their potential biological activities. This can lead to the discovery of new drugs and therapeutic agents with improved efficacy and safety profiles.

InChI:InChI=1/C19H21NO4.ClH/c20-17(19(22)24-14-16-9-5-2-6-10-16)11-12-18(21)23-13-15-7-3-1-4-8-15;/h1-10,17H,11-14,20H2;1H/t17-;/m0./s1

Upstream product

• 56-86-0 L-glutamic acid 
• 100-51-6 benzyl alcohol 
• 2419-94-5 Boc-Glu 
• 80963-14-0 dibenzyl N-tert-butyloxycarbonyl-L-glutamate 

Downstream Products

• 18791-58-7 N-[N-(N-benzyloxycarbonyl-L-leucyl)-L-valyl]-L-glutamic acid dibenzyl ester 
• 302941-54-4 dibenzyl (S)-2-isocyanatopentanedioate 
• 59524-71-9 t-butoxycarbonyl-L-alanyl-L-glutamic acid dibenzyl ester 
• 97656-57-0 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-glutamic acid dibenzyl ester 
• 60219-06-9 dibenzyl methotrexate 
• 79974-10-0 N-methylamino>benzoyl>-L-γ-glutamyl>-L-glutamic acid tribenzyl ester 
• 79974-13-3 N-methylamino>benzoyl>-L-α-glutamyl>-L-glutamic acid tribenzyl ester 
• 157896-18-9 (S)-2-((S)-4-{4-[((5R,6S)-2-Amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-benzyloxycarbonyl-butyrylamino)-pentanedioic acid dibenzyl ester 
• 146963-43-1 (S)-2-{[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-amino}-pentanedioic acid dibenzyl ester 
• 98927-22-1 C₂₇H₃₄N₂O₇ 
• 52574-06-8 (2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid 
• 146963-42-0 N-methyl-L-2-oxopyrrolidine-5-carboxylic acid benzyl ester 
• 146963-41-9 N-methyl-L-glutamic acid dibenzyl ester 
• 146963-40-8 N-methyl-N-(o-nitrobenzyl)-L-glutamic acid dibenzyl ester 

Relevant articles and documents

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders as well as other disorders.

Green preparation method of N-substituted-L-pyroglutamate

The invention provides a green preparation method of N-substituted-L-pyroglutamate. The method comprises the steps as follows: L-glutamic acid diester hydrochloride (III) is prepared from L-glutamic acid (II) as a starting material in the presence of an acidic reagent by an esterification reaction; then, L-glutamic acid diester hydrochloride (III) is subjected to N-substituted protective reactionwith an N-substituent protective reagent with a one-pot method in the presence of a base and a solvent, an N-substituted protective group is introduced, heating is performed for dealcoholization cyclization in molecules, and N-substituted-L-pyroglutamate as shown in the formula (I) is obtained. The method has the advantages of cheap and easily available raw materials, classic reaction types, shortprocess route, simple and convenient operation, small waste water amount, green and environment-friendly production process, high reaction yield and low product cost. 5R-benzyloxyaminopiperidine-2S-carboxylate, 5R-benzyloxyaminopiperidine-2S-formate ethanedioate and avibactam can be prepared from N-substituted-L-pyroglutamate as shown in the formula (I).

Study on synthesis, characteristics and catalysis properties of novel chiral metal complexes catalysts for 1,3-dipolar cycloaddition reactions of nitrone with electron-rich alkene

As a new class of potential catalysts for 1,3-dipolar cycloaddition reactions, fourteen L-amino acid Schiff base Cu(II) and Ti(IV) complexes were synthesized, characterized, and evaluated for their catalytic activities in the reaction between C, N-diphenylnitrone and electron-rich ethyl vinyl ether under both homogeneous and in situ conditions. The methods for preparation and utilization of the catalysts were elucidated in detail, and the results of the catalytic reactions were described and discussed as well. Excellent reaction results were found in the presence of some catalysts (20 mol%) with > 90% endo-isoazolidines produced, compared with predominantly exo-isoazolidine produced without a catalyst. In addition, the reaction rate is found to be enhanced remarkably by a Cu(II) complex Schiff base catalyst at room temperature.