457884-62-7

Basic information

• Product Name: (E)-(8S,11S,17R)-17-(3-Chloro-4-methoxy-benzyl)-8-isobutyl-11-[(S)-1-(3-phenyl-oxiranyl)-ethyl]-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone
• CAS NO: 457884-62-7
• Molecular Weight: 695.253
• Mol File: 457884-62-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-(8S,11S,17R)-17-(3-Chloro-4-methoxy-benzyl)-8-isobutyl-11-[(S)-1-(3-phenyl-oxiranyl)-ethyl]-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(8S,11S,17R)-17-(3-Chloro-4-methoxy-benzyl)-8-isobutyl-11-[(S)-1-(3-phenyl-oxiranyl)-ethyl]-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone(457884-62-7)
• EPA Substance Registry System: (E)-(8S,11S,17R)-17-(3-Chloro-4-methoxy-benzyl)-8-isobutyl-11-[(S)-1-(3-phenyl-oxiranyl)-ethyl]-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone(457884-62-7)

Safety Data

• Hazardous Substances Data: 457884-62-7(Hazardous Substances Data)

Upstream product

• 204514-16-9 1-(tert-butoxycarbonylamino-methyl)-cyclopentanecarboxylic acid 1-allyloxycarbonyl-3-methyl-butyl ester 
• 204514-27-2 1-(tert-butoxycarbonylamino-methyl)-cyclopentanecarboxylic acid 1-carboxy-3-methyl-butyl ester 
• 223763-91-5 tert-butyl {[1-(hydroxymethyl)cyclopentyl]methyl}carbamate 
• 204514-22-7 1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclopentane-1-carboxylic acid 
• 2239-31-8 3-(1-(aminomethyl)cyclopentyl)methanol 
• 28247-14-5 ethyl 1-cyanocyclopentanecarboxylate 
• 223763-96-0 (E)-(8S,11S,17R)-17-(3-Chloro-4-methoxy-benzyl)-8-isobutyl-11-((E)-(R)-1-methyl-3-phenyl-allyl)-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone 

Downstream Products

• 223764-01-0 (E)-(8S,11S,17R)-11-((1R,2R,3S)-3-Chloro-2-hydroxy-1-methyl-3-phenyl-propyl)-17-(3-chloro-4-methoxy-benzyl)-8-isobutyl-7,10-dioxa-16,19-diaza-spiro[4.15]icos-13-ene-6,9,15,18-tetraone 

Relevant articles and documents

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models.