460-08-2 Usage
Description
2-Fluoroethylamine hydrochloride is an organic compound that serves as an important intermediate in the synthesis of various chemical compounds and pharmaceuticals. It is characterized by the presence of a fluoroethyl group attached to an amine moiety, with a hydrochloride counterion. 2-FLUOROETHYLAMINE HYDROCHLORIDE is known for its reactivity and ability to form a wide range of derivatives, making it a versatile building block in organic chemistry and medicinal chemistry.
Uses
Used in Chemical Synthesis:
2-Fluoroethylamine hydrochloride is used as a key intermediate in the synthesis of various chemical compounds, including isocyanates, ureas, and imides. Its reactivity and the presence of the fluoroethyl group make it a valuable component in the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoroethylamine hydrochloride is used as a building block for the development of new drugs and drug candidates. Its incorporation into drug molecules can impart unique properties, such as increased lipophilicity, metabolic stability, and binding affinity, which can lead to improved therapeutic efficacy and safety profiles.
Used in the Synthesis of 2-Fluoroethylisocyanate:
2-Fluoroethylamine hydrochloride is used as a starting material in the synthesis of 2-fluoroethylisocyanate, a valuable compound with potential applications in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in the Synthesis of 1,3-Bis-(2-Fluoroethyl) Urea (BFU):
2-Fluoroethylamine hydrochloride is used in the preparation of 1,3-bis-(2-fluoroethyl) urea (BFU), a compound with potential applications in various industries, including pharmaceuticals, materials science, and chemical research.
Used in the Synthesis of N-2-Fluoroethylmaleimide:
2-Fluoroethylamine hydrochloride is employed in the synthesis of N-2-fluoroethylmaleimide, a compound that can be used as a monomer in the production of polymers with unique properties, such as increased thermal stability and resistance to degradation.
Used in the Synthesis of [Cu4(O)(Ln)2(CH3COO)4] where HL= 4-Methyl-2,6-Bis(2-Fluoroethyliminomethyl) Phenol:
2-Fluoroethylamine hydrochloride is utilized in the preparation of a copper-containing complex, [Cu4(O)(Ln)2(CH3COO)4], where HL is 4-methyl-2,6-bis(2-fluoroethyliminomethyl) phenol. This complex may have potential applications in catalysis, materials science, or as a precursor to other copper-containing compounds.
Used in the Synthesis of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate (FEAnGA):
2-Fluoroethylamine hydrochloride is used in the synthesis of FEAnGA, a compound with potential applications in the development of new drugs, particularly those targeting carbohydrate metabolism or related biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 460-08-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 460-08:
(5*4)+(4*6)+(3*0)+(2*0)+(1*8)=52
52 % 10 = 2
So 460-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C2H6FN/c3-1-2-4/h1-2,4H2
460-08-2Relevant articles and documents
Preparation method of 2-fluoroethylamine hydrochloride
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Page/Page column 4-6, (2021/04/14)
The invention discloses a preparation method of 2-fluoroethylamine hydrochloride. The method comprises the following steps: S1, synthesis of 2-fluoroethyl phthalimide: adding 2-fluoro-1-haloethane and phthalimide potassium into a reaction container, performing dissolving with N,N-dimethylformamide under mechanical stirring, performing reacting, carrying out reduced pressure distillation to recover N,N-dimethylformamide after the reaction is finished, adding water into the reaction container, performing heating and stirring, and performing cooling, filtering and vacuum drying to obtain a 2-fluoroethyl phthalimide intermediate; and S2, synthesis of the 2-fluoroethylamine hydrochloride: adding the 2-fluoroethyl phthalimide intermediate prepared in the step S1 into the reaction container, performing dissolving with ethanol, dropwise adding hydrazine hydrate for reaction, performing cooling after the reaction is finished, adjusting the pH to 5 with hydrochloric acid, performing refluxing for 1 hour, and performing filtering and vacuum drying to obtain white flaky crystal 2-fluoroethylamine hydrochloride. The method is simple in process, green, safe, low in cost and high in yield.
Sustainable organophosphorus-catalysed Staudinger reduction
Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin
supporting information, p. 4418 - 4422 (2018/10/17)
A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.
GROWTH HORMONE SECRETAGOGUES
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Page/Page column 103; 107, (2010/02/07)
This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
