46001-09-6 Usage
General Description
6,7,8,9-tetrahydro-3H-pyrimido[4,5-d]azepin-4(5H)-one, also known as TPA, is a heterocyclic compound with a fused-ring structure. It is a seven-membered ring system containing two nitrogen atoms and one oxygen atom. TPA is a pharmacologically important chemical used in the synthesis of bioactive compounds and pharmaceuticals. It has been studied for its potential anti-inflammatory, anti-cancer, and anti-viral properties. The compound has also been investigated for its neuroprotective effects and potential as a treatment for neurodegenerative diseases. TPA is a versatile building block in organic synthesis, and its unique molecular structure makes it a valuable chemical for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 46001-09-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,6,0,0 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 46001-09:
(7*4)+(6*6)+(5*0)+(4*0)+(3*1)+(2*0)+(1*9)=76
76 % 10 = 6
So 46001-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N3O/c12-8-6-1-3-9-4-2-7(6)10-5-11-8/h5,9H,1-4H2,(H,10,11,12)
46001-09-6Relevant articles and documents
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
Hawryluk, Natalie A.,Merit, Jeffrey E.,Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Swanson, Nadia,Ao, Hong,Maher, Michael P.,Bhattacharya, Anindya,Wang, Qi,Freedman, Jamie M.,Scott, Brian P.,Wickenden, Alan D.,Chaplan, Sandra R.,Breitenbucher, J. Guy
scheme or table, p. 7137 - 7141 (2010/12/25)
Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent antagonists of TRPV1. The tetrahydro-pyrimdoazepines have been identified as having good in vitro and in
