46004-37-9

Basic information

• Product Name: Methyl 4-amino-2-chlorobenzoate
• Synonyms: methyl 4-amino-2-chlorobenzoate(SALTDATA: FREE);Methyl 4-amino-2-chlorobenzoate 2-Chioro-4-aminobenzoic acid methyl ester;METHYL 4-AMINO-2-CHLOROBENZOATE;2-chioro-4-aminobenzoic acid methyl ester;4-AMINO-2-CHLORO-BENZOIC ACID METHYL ESTER;AKOS BB-3102;2-chloro-4-amino benzoic acid methyl ester;Methyl 2-Chloro-4-Aminobenzoate
• CAS NO: 46004-37-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: Phenylacetic acid;Miscellaneous;Benzenes;Aromatic Esters
• Mol File: 46004-37-9.mol
• Article Data: 30

Chemical Properties

• Melting Point: 112-114°C
• Boiling Point: 334.207 °C at 760 mmHg
• Flash Point: 155.923 °C
• Appearance: /
• Density: 1.311 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Chloroform
• PKA: 1.41±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-amino-2-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-2-chlorobenzoate(46004-37-9)
• EPA Substance Registry System: Methyl 4-amino-2-chlorobenzoate(46004-37-9)

Safety Data

• Hazardous Substances Data: 46004-37-9(Hazardous Substances Data)

Usage

Description

Methyl 4-amino-2-chlorobenzoate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is characterized by the presence of an amino group, a chloro substituent, and a benzene ring, which contribute to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
Methyl 4-amino-2-chlorobenzoate is used as a reagent for the synthesis of selective Liver X Receptor (LXR) agonists. These agonists are designed to increase High-Density Lipoprotein (HDL) levels and promote reverse cholesterol transport in mice, which can potentially lead to the development of novel treatments for dyslipidemia and related cardiovascular conditions.

InChI:InChI=1/C8H8ClNO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3

Upstream product

• 67-56-1 methanol 
• 38667-55-9 4-Acetylamino-2-chlorobenzoic acid 
• 13324-11-3 methyl 2-chloro-4-nitrobenzoate 
• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 75-36-5 acetyl chloride 
• 77-78-1 dimethyl sulfate 
• 99-60-5 2-chloro-4-nitrobenzoic acid 

Downstream Products

• 103859-12-7 4-amino-2-chloro-benzoic acid-(2-dimethylamino-ethyl ester) 
• 211040-40-3 2-Chloro-4-(5-fluoro-2-methyl-benzoylamino)-benzoic acid methyl ester 
• 88-06-2 2,4,6-Trichlorophenol 
• 935676-14-5 methyl 4-amino-2-chloro-3-iodo-benzoate 
• 256935-85-0 methyl 4-amino-2-chloro-5-iodo-benzoate 
• 911313-97-8 Methyl 2-chloro-4-(3-ethoxycarbonylpropylamino)benzoate 
• 935676-08-7 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-benzoic acid methyl ester 

Relevant articles and documents

Synthesis of a coronene analogue containing an amide bond by Pd-mediated intramolecular C[sbnd]C bond formation of 2-halogenated 4-(alkylamino)benzoic acid cyclic trimer

A coronene analogue containing amide linkage was synthesized from a halogenated cyclic triamide by palladium-mediated intramolecular C[sbnd]C bond formation. The cyclic triamide was formed from the condensation of 2-chloro-4-(isobutylamino)benzoic acid in

PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

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The present invention provides compounds, compositions thereof, and methods of using the same.