460053-59-2

Basic information

• Product Name: 3-benzoyl-6-azaindole
• Synonyms: 3-benzoyl-6-azaindole
• CAS NO: 460053-59-2
• Molecular Formula: C14H10N2O
• Molecular Weight: 222
• Mol File: 460053-59-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-benzoyl-6-azaindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoyl-6-azaindole(460053-59-2)
• EPA Substance Registry System: 3-benzoyl-6-azaindole(460053-59-2)

Safety Data

• Hazardous Substances Data: 460053-59-2(Hazardous Substances Data)

Upstream product

• 271-29-4 6-azaindole 
• 98-88-4 benzoyl chloride 
• 908847-23-4 (E)-N,N-dimethyl-2-(3-nitropyridin-4-yl)ethenamine 
• 5832-44-0 3-nitro-4-methylpyridine 

Relevant articles and documents

An effective procedure for the preparation of 3-substituted-4- or 6-azaindoles from ortho-methyl nitro pyridines

3-Substituted-4- and 6-azaindoles were prepared from ortho-methyl-nitropyridines in a practically convenient, one-pot process based on the Leimgruber-Batcho reaction. The procedure comprises a sequence of (a) condensation of an ortho-methyl-nitropyridine with N,N-dimethylformamide dimethyl acetal; (b) alkylation or acylation of the enamine intermediate; (c) reduction of the nitro group to an aniline with in situ cyclization and elimination of dimethylamine to generate the 3-substituted azaindole heterocycle.

An effective procedure for the acylation of azaindoles at C-3

Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl3 in CH2Cl2 followed