460345-72-6Relevant articles and documents
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1
Lorthiois, Edwige,Bernardelli, Patrick,Vergne, Fabrice,Oliveira, Chrystelle,Mafroud, Abdel-Kader,Proust, Emmanuelle,Heuze, Lamia,Moreau, Fran?ois,Idrissi, Moulay,Tertre, Anita,Bertin, Bernadette,Coupe, Magali,Wrigglesworth, Roger,Descours, Arnaud,Soulard, Patricia,Berna, Patrick
, p. 4623 - 4626 (2004)
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
