46147-15-3

Basic information

• Product Name: 3-carboxy proxyl
• CAS NO: 46147-15-3
• Molecular Weight: 186.231
• Mol File: 46147-15-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-carboxy proxyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3-carboxy proxyl(46147-15-3)
• EPA Substance Registry System: 3-carboxy proxyl(46147-15-3)

Safety Data

• Hazardous Substances Data: 46147-15-3(Hazardous Substances Data)

Upstream product

• 96623-58-4 1-hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine 
• 46247-54-5 3‐methoxycarbonyl‐2,2,5,5‐tetramethyl‐pyrrolidine‐1‐oxyl 
• 81635-38-3 3-bromo-2,2,6,6-tetramethyl-1-oxyl-piperidine-4-one 

Downstream Products

• 106905-00-4 iron(III) 5,10,15,20-tetra-p-tolylporphyrin 2,2,5,5-tetramethyl-1-oxypyrrolidine-3-carboxylate 
• 56948-70-0 cortisol 21-(2,2,5,5-tetramethylpyrrolidin-1-yloxy)-3-carboxylate 
• 58537-73-8 1-oxyl-2,2,5,5-tetramethylpyrrolidinyl-3-carboxylic acid N-hydroxysuccinimide ester 
• 928310-71-8 1-hydroxy-3-(((carbonyl)oxy)butyltriphenylphosphonium)-2,2,5,5-tetramethylpyrrolidine bromide 
• 1352203-38-3 C₁₃H₂₀NO₅ 
• 1599434-86-2 C₁₃H₂₀NO₅ 
• 1425495-88-0 3'-N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinylcarbonyl)-amido-AVE8063 
• 1391158-78-3 C₂₇H₃₄NO₇ 

Relevant articles and documents

Facile synthesis of 3-methoxycarbonyl-2,2,5,5-tetra-methylpyrrolidine-1-oxyl and derivatives

We have achieved an efficient alternative synthesis of blood-brain-barrier permeable nitroxyl radicals 3-methoxycarbonyl-2,2,5,5-tetra-methylpyrrolidine-1-oxyl (1a) and 3-ethoxycarbonyl-2,2,5,5-tetramethylpyrroli-dine-1-oxyl (1b), which affords 1a and 1b in 65% isolated yields by four steps from 2,2,6.6-tetramethyl-4-piperidone (2), respectively. This protocol is applicable to the synthesis of 3-isopropoxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl (1c) and 3-carbonyl-2,2,5,5-tetramethylpyrro-lidine-1-oxyl (6).

A Study of the Favorskii Rearrangement with 3-Bromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-oxyl

Favorskii rearrangement reactions of the title compound with sodium hydroxide, sodium ethoxide, ammonia, several aliphatic amines, and ethyl sodiomalonate resulting in pyrrolidine nitroxyl radicals are described.