463356-12-9Relevant articles and documents
Synthesis and evaluation of N-substituted 1,4-oxazepanyl Sordaricins as selective fungal EF-2 inhibitors.
Kaneko, Satoru,Arai, Masami,Uchida, Takuya,Harasaki, Tamako,Fukuoka, Takashi,Konosu, Toshiyuki
, p. 1705 - 1708 (2007/10/03)
Sordaricin analogues possessing 6-methoxy-7-methyl-1,4-oxazepane moiety instead of the sugar part were synthesized and evaluated. It was found that N-substituents on the oxazepane ring had influence on biological activity. In particular, N-(2-methylpropenyl) derivative 12p exhibited potent in vitro antifungal activity. Furthermore, 12p maintained significant activity (MIC 0.25 microg/mL) against Candida albicans SANK51486 even in the presence of 20% horse serum.