4636-51-5Relevant articles and documents
Hree-component reaction of benzylamines, diethyl phosphite and triethyl orthoformate: Dependence of the reaction course on the structural features of the substrates and reaction conditions
Miszczyk, Atrycja,Turowska-Tyrk, Ilona,Kafarski, Pawel,Chmielewska, Ewa
, (2017/03/24)
The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.
Selective N-methylation of aliphatic amines with CO2 and hydrosilanes using nickel-phosphine catalysts
Gonzlez-Sebastin, Lucero,Flores-Alamo, Marcos,Garca, Juventino J.
, p. 763 - 769 (2015/05/12)
A method using CO2 and PhSiH3 for the methylation of primary and secondary aliphatic amines catalyzed by Ni (0) complexes was developed, selectively producing the monomethylated products in moderate to good yields. For that purpose, two catalysts were used: [(dippe)Ni(μ-H)]2 and the commercially available Ni(COD)2/dcype, both of which were rather efficient in this process. With a slight experimental modification, the reaction allowed the production of monomethylated ureas in good yields by using low amounts of PhSiH3. On the basis of the experimental results, we propose a possible reaction mechanism for the formation of the new C-N bond.
Pushing back the limits of hydrosilylation: Unprecedented catalytic reduction of organic ureas to formamidines
Pouessel, Jacky,Jacquet, Olivier,Cantat, Thibault
, p. 3552 - 3556 (2014/01/06)
Pushing back the limits: A novel catalytic transformation has been designed to prepare formamidine derivatives by reduction of substituted ureas with hydrosilanes. Simple iron catalysts based on commercially available iron salts and phosphine ligands prov
