470463-38-8

Basic information

• Product Name: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER
• Synonyms: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER;Methyl 2-pivalamidoisonicotinate
• CAS NO: 470463-38-8
• Molecular Formula: C12H16N2O3
• Molecular Weight: 236.27
• Mol File: 470463-38-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 75.1-75.2°C
• Boiling Point: 412.7 ºC at 760 mmHg
• Flash Point: 203.4 ºC
• Appearance: /
• Density: 1.162 g/cm³
• Vapor Pressure: 5.08E-07mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER(470463-38-8)
• EPA Substance Registry System: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER(470463-38-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 470463-38-8(Hazardous Substances Data)

Usage

General Description

2-(2,2-Dimethyl-propionylamino)-isonicotinic acid methyl ester is a chemical compound with the molecular formula C14H19N3O2. It is a methyl ester derivative of isonicotinic acid, and contains a propionylamino group. 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER is used in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the development of new drugs for the treatment of various medical conditions, and is also used as a reagent in organic chemistry research. Its molecular structure and properties make it a versatile building block for the creation of novel chemical compounds with potential therapeutic uses.

InChI:InChI=1/C12H16N2O3/c1-12(2,3)11(16)14-9-7-8(5-6-13-9)10(15)17-4/h5-7H,1-4H3,(H,13,14,16)

Upstream product

• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13362-28-2 2-aminoisonicotinic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 

Downstream Products

• 639091-77-3 tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate 

Relevant articles and documents

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION

Compounds of formulae (I) and (II), compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells invivo, in vitro, or ex vivo.

A multifunctional reagent designed for the site-selective amination of pyridines

We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site selectivity and chemoselectivity. The novel reagent was prepared on 200-g scale in a single step, reacts in the title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Experimental and in situ spectroscopic monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.