4732-82-5 Usage
Description
3'-Monoiodothyronine, also known as 3'-Iodo-L-thyronine, is a metabolite of thyroid hormone that plays a crucial role in the optimal development of the human central nervous system. It is a derivative of thyronine with an iodine atom attached at the 3' position, which contributes to its biological activity and function.
Uses
Used in Pharmaceutical Industry:
3'-Monoiodothyronine is used as a pharmaceutical agent for its role in promoting the development and maintenance of the central nervous system. It is particularly important for the proper growth and function of the brain and nervous system in infants and children.
Used in Research Applications:
In the field of research, 3'-monoiodothyronine is used as a biochemical marker to study the effects of thyroid hormones on various physiological processes. It helps researchers understand the role of thyroid hormones in brain development, metabolism, and other bodily functions.
Used in Diagnostic Applications:
3'-Monoiodothyronine can also be used as a diagnostic tool to assess thyroid function and monitor the effectiveness of treatments for thyroid disorders. Its measurement in blood samples can provide valuable information about an individual's thyroid hormone levels and overall thyroid health.
Check Digit Verification of cas no
The CAS Registry Mumber 4732-82-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,3 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4732-82:
(6*4)+(5*7)+(4*3)+(3*2)+(2*8)+(1*2)=95
95 % 10 = 5
So 4732-82-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H14INO4/c16-12-8-11(5-6-14(12)18)21-10-3-1-9(2-4-10)7-13(17)15(19)20/h1-6,8,13,18H,7,17H2,(H,19,20)/t13-/m0/s1
4732-82-5Relevant articles and documents
Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones
Raja, Karuppusamy,Mugesh, Govindasamy
supporting information, p. 7674 - 7678 (2015/06/25)
Iodothyronine deiodinases are selenoenzymes which regulate the thyroid hormone homeostasis by catalyzing the regioselective deiodination of thyroxine (T4). Synthetic deiodinase mimetics are important not only to understand the mechanism of enzyme catalysis, but also to develop therapeutic agents as abnormal thyroid hormone levels have implications in different diseases, such as hypoxia, myocardial infarction, critical illness, neuronal ischemia, tissue injury, and cancer. Described herein is that the replacement of sulfur/selenium atoms in a series of deiodinase mimetics by tellurium remarkably alters the reactivity as well as regioselectivity toward T4. The tellurium compounds reported in this paper represent the first examples of deiodinase mimetics which mediate sequential deiodination of T4 to produce all the hormone derivatives including T0 under physiologically relevant conditions.