47623-98-3

Basic information

• Product Name: BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL
• Synonyms: bis(1,3-diethylthiobarbiturate)trimethineoxonol;BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL;DISBAC2(3);NEURODYE DISBAC2(3);5-[2-allylidene-3-(1,3-diethylhexahydro-4,6-dioxo-2-thioxopyrimidin-5-yl)]-1,3-diethyldihydro-2-thioxo-1H,5H-pyrimidine-4,6-dione;Neurodye disbac2(3), pure;5-(3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propenylidene)-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;DiSBAC2(3) [Bis-(1,3-diethylthiobarbituric acid) triMethine oxonol]
• CAS NO: 47623-98-3
• Molecular Formula: C19H24N4O4S2
• Molecular Weight: 436.56
• EINECS: 256-325-5
• Product Categories: Oxonol
• Mol File: 47623-98-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 464.7°C at 760 mmHg
• Flash Point: 234.8°C
• Appearance: Purple/powder
• Density: 1.42g/cm³
• Vapor Pressure: 1.38E-10mmHg at 25°C
• Refractive Index: 1.684
• Storage Temp.: ?20°C
• Solubility: Soluble in ethanol, methanol, dimethyl sulfoxide
• BRN: 1232950
• CAS DataBase Reference: BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL(CAS DataBase Reference)
• NIST Chemistry Reference: BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL(47623-98-3)
• EPA Substance Registry System: BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL(47623-98-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 47623-98-3(Hazardous Substances Data)

Usage

Description

BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL, also known as DISBAC2(3), is a voltage-sensitive fluorescent probe used for single-cell fluorescence imaging. It is a unique compound that allows for the visualization of transmembrane conductance and potential changes in individual cells.

Uses

Used in Neuroscience Research:
BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL is used as a voltage-sensitive probe for single-cell fluorescence imaging of transmembrane conductance and potential change. This allows researchers to study the electrical activity of cells, particularly neurons, in real-time and with high spatial resolution.
Used in Drug Screening and Development:
In the pharmaceutical industry, BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL can be used as a tool for drug screening and development. By monitoring the effects of potential drugs on cell membrane potential, researchers can gain insights into the mechanisms of action and efficacy of these compounds.
Used in Cell Biology Studies:
BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL can also be employed in cell biology research to investigate the properties and functions of ion channels, transporters, and other membrane proteins. This can help researchers better understand the complex processes that govern cell function and communication.
Overall, BIS-(1,3-DIETHYLTHIOBARBITURIC ACID)TRIMETHINE OXONOL is a valuable tool in various scientific fields, particularly in the study of cell membrane dynamics and the development of new therapeutic agents.

InChI:InChI=1/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-11,24H,5-8H2,1-4H3