476314-27-9Relevant articles and documents
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production
Laughlin, Steven K.,Clark, Michael P.,Djung, Jane F.,Golebiowski, Adam,Brugel, Todd A.,Sabat, Mark,Bookland, Roger G.,Laufersweiler, Matthew J.,VanRens, John C.,Townes, Jennifer A.,De, Biswanath,Hsieh, Lily C.,Xu, Susan C.,Walter, Richard L.,Mekel, Marlene J.,Janusz, Michael J.
, p. 2399 - 2403 (2007/10/03)
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-α production.