476454-79-2

Basic information

• Product Name: ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-[(4-methylphenyl)amino]propenoate
• Synonyms: ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-[(4-methylphenyl)amino]propenoate
• CAS NO: 476454-79-2
• Molecular Weight: 350.374
• Mol File: 476454-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-[(4-methylphenyl)amino]propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-[(4-methylphenyl)amino]propenoate(476454-79-2)
• EPA Substance Registry System: ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-[(4-methylphenyl)amino]propenoate(476454-79-2)

Safety Data

• Hazardous Substances Data: 476454-79-2(Hazardous Substances Data)

Upstream product

• 6974-10-3 phthalimidoacetic acid ethyl ester 
• 106-49-0 p-toluidine 
• 476454-78-1 ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-(dimethylamino)propenoate 

Relevant articles and documents

Synthesis and transformations of ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-(dimethylamino)propenoate

Ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-(dimethylamino)propenoate was prepared in one step from ethyl (2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)acetate and bis(dimethylamino)-tert-butoxymethane and treated with various amines and hydrazines to afford the corresponding amino substituted products. Reactions of the titled compound with N,N′-, C,N-, and C, O′-ambident nucleophiles in refluxing acetic acid furnished the corresponding fused pyrimidinones, quinolizinones, and pyranones.