4765-77-9

Basic information

• Product Name: 6-Chloropyrimidin-4(3H)-one
• Synonyms: 6-CHLOROPYRIMIDIN-4(3H)-ONE;6-CHLOROPYRIMIDIN-4-OL;6-Chloro-4-pyrimidinol;6-CHLORO-4-HYDROXYPYRIMIDINE;4(1H)-Pyrimidinone, 6-chloro- (9CI);6-Chloro-4(1H)-Pyrimidinone;6-CHLORO-4-HYDROXYPYRIMIDINE,98%;6-chloropyrimidin-4(1H)-one
• CAS NO: 4765-77-9
• Molecular Formula: C₄H₃ClN₂O
• Molecular Weight: 130.53
• EINECS: 1533716-785-6
• Product Categories: PYRIMIDINE;APIs & Intermediate;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Heterocycles;Heterocycle-Pyrimidine series
• Mol File: 4765-77-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 194 °C
• Boiling Point: 199.42 °C at 760 mmHg
• Flash Point: 74.407 °C
• Appearance: off-white to pale yellowish solid
• Density: 1.553 g/cm³
• Vapor Pressure: 0.342mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Refrigerator
• Solubility: DMSO, Water
• PKA: 6.92±0.40(Predicted)
• CAS DataBase Reference: 6-Chloropyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyrimidin-4(3H)-one(4765-77-9)
• EPA Substance Registry System: 6-Chloropyrimidin-4(3H)-one(4765-77-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 22-26-36/37/39-39
• Hazardous Substances Data: 4765-77-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellowish Solid

Uses

4-Chloro-6-hydroxypyrimidine (cas# 4765-77-9) is a compound useful in organic synthesis.

InChI:InChI=1/C4H3ClN2O/c5-3-1-4(8)7-2-6-3/h1-2H,(H,6,7,8)

Upstream product

• 26452-81-3 4-chloro-6-methoxy-pyrimidine 
• 1193-21-1 4,6-dichloropyrimidine 
• 77287-34-4 formamide 

Downstream Products

• 93118-59-3 4-(2,3-Dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-<<2-<(3,4-dihydro-4-oxopyrimidin-6-yl)amino>ethoxy>methyl>-1,4-dihydropyridine 
• 94295-28-0 6-(1-benzylhydrazino)-4(3H)-pyrimidinone 
• 94295-29-1 6-(1-methylhydrazino)pyrimidin-4(3H)-one 
• 26423-00-7 butyl-(6-chloro-pyrimidin-4-yl)-amine 
• 88982-91-6 4,5-Dichlor-6-hydroxy-pyrimidin 
• 1159567-58-4 6-[4-(3-fluoro-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one 
• 130841-08-6 6-(4-chlorophenyl)-3H-pyrimidin-4-one 
• 1243253-47-5 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-pyrimidin-4(3H)-one 
• 99185-53-2 6-anilino-3H-pyrimidin-4-one 
• 1419746-97-6 C₁₅H₁₅N₃O₂ 
• 101079-62-3 6-chloro-3-methylpyrimidin-4(3H)-one 
• 29939-37-5 4-hydrazino-6-hydroxypyrimidine 
• 3137-56-2 6-chloro-5-nitro-pyrimidin-4-ol 
• 6128-06-9 4-Hydroxy-6-methoxy-pyrimidin 

Relevant articles and documents

Visible-Light-Induced Radical Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF2H-Substituted Quinazolinones

A mild and efficient visible-light-induced radical difluoromethylation/cyclization of unactivated alkenes toward the synthesis of substituted quinazolinones with easily accessible difluoromethyltriphenylphosphonium bromide has been developed. The transformation has the advantages of wide functional group compatibility, a broad substrate scope, and operational simplicity. The benign protocol offers a facile access to pharmaceutically valuable difluoromethylated polycyclic quinazolinones.

FXIa blood coagulation factor inhibitor as well as pharmaceutical composition and application thereof

The invention relates to an FXIa blood coagulation factor inhibitor as well as a pharmaceutical composition and application thereof. Specifically, the invention discloses a compound shown as a formulaI or a pharmaceutically acceptable salt thereof. The invention also discloses a pharmaceutical composition containing the compound as shown in the formula I or pharmaceutically acceptable salt thereof, and application of the compound as shown in the formula I or pharmaceutically acceptable salt thereof. The compound disclosed by the invention is novel in structure and has good inhibitory activityon FXIa. .

Design, synthesis, and antifungal activities of new β-methoxyacrylate analogues

Strobilurins have become one of the most important classes of agricultural fungicides. To search for new strobilurin derivatives with high activity against resistant pathogens, a series of new β-methoxyacrylate analogues containing substituted pyrimidine in the side chain with strobilurin pharmacophore were synthesized and their biological activities were tested. The compounds were confirmed and characterized by 1H-NMR, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activities against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at a concentration of 50 μg mL-1. Notably, compound 1b (R = 2,5-dimethylphenyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.