477781-69-4

Basic information

• Product Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
• Synonyms: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate;Benzyl-PEG4-MS
• CAS NO: 477781-69-4
• Molecular Formula: C₁₆H₂₆O₇S
• Molecular Weight: 362.43844
• Mol File: 477781-69-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(477781-69-4)
• EPA Substance Registry System: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate(477781-69-4)

Safety Data

• Hazardous Substances Data: 477781-69-4(Hazardous Substances Data)

Usage

Chemical class

methanesulfonates

Derivative

methanesulfonic acid

Carbon chain length

13 carbons

Oxygen atoms

4 at specific positions (2, 5, 8, 11)

Aromatic compound

due to the presence of a phenyl group

Common use

as a reagent in organic synthesis reactions and as a protecting group for alcohol functional groups

Importance

unique structure and reactivity make it valuable in organic chemistry research and synthesis applications.

Upstream product

• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 124-63-0 methanesulfonyl chloride 
• 112-60-7 Tetraethylene glycol 
• 100-44-7 benzyl chloride 
• 112-76-5 Stearoyl chloride 
• 477775-73-8 1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 951260-63-2 C₁₉H₃₃NO₆ 
• 86770-71-0 ((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene 
• 951260-37-0 C₃₂H₃₁F₂₇O₈ 
• 499136-63-9 (4R)-2,2-dimethyl-4-(15-phenyl-2,5,8,11,14-pentaoxapentadecyl)-1,3-dioxolane 
• 351342-08-0 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol 
• 6790-09-6 dodecaethylene glycol 
• 1053658-70-0 octacosakis(ethylene glycol) 
• 477775-73-8 1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol 
• 1616876-40-4 1,2-di-O-octadecyl-3-O-(13-phenyl-3,6,9,12-tetraoxatridecyl)-sn-glycerol 
• 1616876-38-0 1,2-O-isopropylidene-3-O-(13-phenyl-3,6,9,12-tetraoxatridecyl)-sn-glycerol 
• 1003598-46-6 C₁₈H₂₇F₃O₅ 
• 70802-40-3 stearate-PEG8 oligomer 
• 86770-76-5 2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethanamine 

Relevant articles and documents

A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.

Propargylamine-isothiocyanate reaction: Efficient conjugation chemistry in aqueous media

A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method. This journal is the Partner Organisations 2014.

HIGHLY FLUORINATED OILS AND SURFACTANTS AND METHODS OF MAKING AND USING SAME

Disclosed are compounds comprising the structure (I): In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for