4784-41-2

Basic information

• Product Name: 3',5'-di-O-p-toluoyl-α-2'-deoxythymidine
• CAS NO: 4784-41-2
• Molecular Weight: 478.502
• Mol File: 4784-41-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3',5'-di-O-p-toluoyl-α-2'-deoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-di-O-p-toluoyl-α-2'-deoxythymidine(4784-41-2)
• EPA Substance Registry System: 3',5'-di-O-p-toluoyl-α-2'-deoxythymidine(4784-41-2)

Safety Data

• Hazardous Substances Data: 4784-41-2(Hazardous Substances Data)

Upstream product

• 3056-13-1 3',5'-di-O-p-toluoyl-2'-deoxythymidine 
• 50-89-5 thymidine 
• 874-60-2 4-methyl-benzoyl chloride 
• 4449-39-2 3',5'-di-O-toluoylthymidine 
• 4330-34-1 methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose 
• 10416-59-8 N,O-Bis(trimethylsilyl)acetamide 
• 65-71-4 thymin 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 

Downstream Products

• 4449-43-8 α-deoxythymidine 
• 3056-13-1 3',5'-di-O-p-toluoyl-α-2'-deoxythymidine 
• 114988-00-0 Phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 104766-16-7 5'-O-(4,4'-dimethoxytrityl)-α-thymidine 

Relevant articles and documents

Synthesis of α-2'-deoxynucleosides

α-Thyimdine (4) was synthesized from thyimdine (1) in 3 steps in 36% overall yield without using chromatography and with the possibility of increasing the yield to 85% by reusing the remaining α,β-mixture. 1-(2-Deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofu

Investigation of Stereoselectivities in the Coupling Reactions of 1-O-Methyl-3,5-di-O-p-toluoyl-2-deoxyribofuranoside with Purines and Pyrimidines

Stereoselectivities in the coupling rection between 1-O-methyl-3,5-di-O-p-toluoyl-2-deoxyribofuranoside and suitably protected purine and pyrimidine derivatives have been examined in acetonitrile with varying equivalents of SnCl4.The best result in α-nucleoside formation was obtained when the coupling reaction was carried out in the presence of ten equivalents of SnCl4.

Novel DNA Analog for Potential Gene Regulating Agent. A Convenient Synthesis of α-Oligodeoxyribonucleotide Phosphorothioate Bearing 3'-Monophosphate

α-2'-Deoxyoctathymydilic acid phosphorothioate analog bearing 3'-monophosphate was conveniently synthesized via phosphoramidite method using a riboadenosine attached Teflon-based solid support.The obtained oligomer exhibited enhanced stability toward the digestion by common nucleases.