478518-95-5 Usage
Description
2-Deoxy-2-fluoro-D-[1-13C]glucose is an isotope-labeled analogue of 2-deoxy-3-fluoro-D-glucose (D234500), which serves as a substrate for hexokinase isozymes. 2-DEOXY-2-FLUORO-D-[1-13C]GLUCOSE is characterized by the replacement of a hydrogen atom with a fluorine atom at the 2-position and the incorporation of a 13C isotope at the 1-position of the glucose molecule. This modification allows for the study of metabolic pathways and enzyme interactions with enhanced sensitivity and specificity.
Uses
Used in Pharmaceutical Industry:
2-Deoxy-2-fluoro-D-[1-13C]glucose is used as a research tool for investigating the role of hexokinase isozymes in various metabolic processes. The incorporation of the 13C isotope enables the tracking of glucose metabolism in living organisms, providing valuable insights into the mechanisms of action and potential therapeutic targets for diseases related to glucose metabolism.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, 2-deoxy-2-fluoro-D-[1-13C]glucose can be utilized as a radiotracer for positron emission tomography (PET) scans. The isotope labeling allows for the detection and monitoring of glucose uptake in tissues, which can be particularly useful in identifying areas of abnormal glucose metabolism, such as tumors or areas of inflammation.
Used in Biochemical Research:
2-Deoxy-2-fluoro-D-[1-13C]glucose is employed as a biochemical research compound to study the kinetics and mechanisms of hexokinase enzymes. The isotope labeling provides a means to differentiate between the natural glucose molecule and the analogue, allowing researchers to investigate enzyme specificity and the effects of the fluorine substitution on enzyme activity.
Used in Drug Development:
In the drug development industry, 2-deoxy-2-fluoro-D-[1-13C]glucose can be used as a starting material or a probe to design and optimize new drugs targeting hexokinase enzymes. The isotope labeling can aid in the identification of potential drug candidates with improved selectivity and efficacy, as well as in the evaluation of their pharmacokinetic and pharmacodynamic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 478518-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,5,1 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 478518-95:
(8*4)+(7*7)+(6*8)+(5*5)+(4*1)+(3*8)+(2*9)+(1*5)=205
205 % 10 = 5
So 478518-95-5 is a valid CAS Registry Number.
