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478965-00-3

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478965-00-3 Usage

General Description

The chemical compound "(4-isopropylphenyl)(2-nitro-5-(prop-2-ynyloxy)phenyl)methanone" is a complex organic compound consisting of a combination of isopropyl, nitro, and prop-2-ynyloxy groups attached to a phenylmethanone core. It is a yellow crystalline solid that is commonly used in the field of organic synthesis and chemical research. The compound possesses a range of potential applications, including as a building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it exhibits various reactivity and functional group compatibility, making it a versatile intermediate in the development of diverse chemical compounds. Overall, the compound holds significance in the field of organic chemistry due to its unique structure and potential applications.

Check Digit Verification of cas no

The CAS Registry Mumber 478965-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,9,6 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 478965-00:
(8*4)+(7*7)+(6*8)+(5*9)+(4*6)+(3*5)+(2*0)+(1*0)=213
213 % 10 = 3
So 478965-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H17NO4/c1-4-11-24-16-9-10-18(20(22)23)17(12-16)19(21)15-7-5-14(6-8-15)13(2)3/h1,5-10,12-13H,11H2,2-3H3

478965-00-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-nitro-5-prop-2-ynoxyphenyl)-(4-propan-2-ylphenyl)methanone

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:478965-00-3 SDS

478965-00-3Relevant articles and documents

L-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A novel series of potent calcium-sensing receptor antagonists

Widler, Leo,Altmann, Eva,Beerli, René,Breitenstein, Werner,Bouhelal, Rochdi,Buhl, Thomas,Gamse, Rainer,Gerspacher, Marc,Halleux, Christine,John, Markus R.,Lehmann, Hansjoerg,Kalb, Oskar,Kneissel, Michaela,Missbach, Martin,Müller, Irene R.,Reidemeister, Sibylle,Renaud, Johanne,Taillardat, Agnes,Tommasi, Ruben,Weiler, Sven,Wolf, Romain M.,Seuwen, Klaus

supporting information; experimental part, p. 2250 - 2263 (2010/08/21)

Parathyroid hormone (PTH) is an effective bone anabolic agent. However, only when administered by daily sc injections exposure of short duration is achieved, a prerequisite for an anabolic response. Instead of applying exogenous PTH, mobilization of endogenous stores of the hormone can be envisaged. The secretion of PTH stored in the parathyroid glands is mediated by a calcium sensing receptor (CaSR) a GPCR localized at the cell surface. Antagonists of CaSR (calcilytics) mimic a state of hypocalcaemia and stimulate PTH release to the bloodstream. Screening of the internal compound collection for inhibition of CaSR signaling function afforded 2a. In vitro potency could be improved > 1000 fold by optimization of its chemical structure. The binding mode of our compounds was predicted based on molecular modeling and confirmed by testing with mutated receptors. While the compounds readily induced PTH release after iv application a special formulation was needed for oral activity. The required profile was achieved by using microemulsions. Excellent PK/PD correlation was found in rats and dogs. High levels of PTH were reached in plasma within minutes which reverted to baseline in about 1-2 h in both species.

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