4792-57-8

Basic information

• Product Name: ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate
• Synonyms: ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate
• CAS NO: 4792-57-8
• Molecular Weight: 236.271
• EINECS: -0
• Mol File: 4792-57-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate(4792-57-8)
• EPA Substance Registry System: ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate(4792-57-8)

Safety Data

• Hazardous Substances Data: 4792-57-8(Hazardous Substances Data)

Usage

General Description

Ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate is a chemical compound with the molecular formula C12H16N2O3. It is also known by the trade name "Ethyl ferulate." ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate is an ester derivative of ferulic acid and is commonly used in the pharmaceutical and cosmetic industries. It has been found to have antioxidant and anti-inflammatory properties, making it useful in the formulation of skincare products and as a potential candidate for the development of new drugs. Additionally, ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate has shown potential in research related to its role in preventing and treating various diseases.

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 89693-83-4 N-Nitroso-p-methoxyanilin 
• 4792-56-7 ethyl 2-(4-methoxyphenylazo)-2-methyl-3-oxobutanoate 
• 4346-59-2 para-methoxyphenyldiazonium chloride 
• 104-94-9 4-methoxy-aniline 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 17333-79-8 p-methoxybenzenediazonium 

Downstream Products

• 1159692-52-0 4-formyl-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 
• 1159691-45-8 ethyl 4-formyl-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate 
• 4382-54-1 5-methoxy-1H-indole-2-carboxylic acid 
• 4792-58-9 ethyl 5-methoxy-1H-indole-2-carboxylate 

Relevant articles and documents

Rh(II)-catalyzed intramolecular annulation of N-sulfonyl 1,2,3-triazoles with indole derivatives: A new method for synthesis pyranoindoles

A direct and highly stereoselective approach for the synthesis of Z-alkenyl-pyranoindoles had been developed by utilizing Rh(II)-catalyzed intramolecular cyclization of N-sulfonyl-1,2,3-triazoles with indole derivatives. A variety of pyranoindoles were obtained in 44-93% yields. Moreover, a more convenient synthesis of pyranoindoles starting from terminal alkyne was realized via a Cu-Rh sequentially catalyzed one-pot cascade reaction.

Process development of 5-methoxy-1H-indole-2-carboxylic acid from ethyl 2-methylmalonate

Development is described of a new process for the preparation from malonates of 5-methoxy-1H-indole-2-carboxylic acid esters, useful intermediates in the synthesis of pharmaceutical compounds. The process uses readily available starting materials, produces little waste, can be operated safely on at least 1 molar scale, and gives high yields. The main areas of optimization included the azo coupling of a diazonium salt with malonate derivatives, the Japp-Klingemann rearrangement, and the Fischer indole synthesis.