479546-79-7

Basic information

• Product Name: N-[6-(2-chloro-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide
• Synonyms: N-[6-(2-chloro-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide
• CAS NO: 479546-79-7
• Molecular Weight: 368.823
• Mol File: 479546-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[6-(2-chloro-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[6-(2-chloro-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide(479546-79-7)
• EPA Substance Registry System: N-[6-(2-chloro-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide(479546-79-7)

Safety Data

• Hazardous Substances Data: 479546-79-7(Hazardous Substances Data)

Upstream product

• 873-31-4 2-chlorophenylacetylene 
• 143682-15-9 6-iodo-4(3H)-oxo-2-pivaloylamino-7H-pyrrolo<2,3-d>pyrimidine 

Downstream Products

• 479546-86-6 N-{6-[2-(2-chloro-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide 

Relevant articles and documents

2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidines as potential inhibitors of thymidylate synthase [1]

Classical, antifolate inhibitors of thymidylate synthase often suffer from a number of potential disadvantages when used as antitumor agents. These include impaired uptake due to an alteration of the active transport system required for cellular uptake, a