4797-43-7

Basic information

• Product Name: 6-CHLORO-4-PHENYLQUINAZOLIN-2(1H)-ONE
• Synonyms: IFLAB-BB F0014-0931;6-CHLORO-4-PHENYLQUINAZOLIN-2(1H)-ONE;6-chloro-4-phenyl-1H-quinazolin-2-one;6-Chloro-4-phenyl-2(1H)-quinazolinone
• CAS NO: 4797-43-7
• Molecular Formula: C₁₄H₉ClN₂O
• Molecular Weight: 256.69
• Mol File: 4797-43-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 490.9°C at 760 mmHg
• Flash Point: 250.7°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 2.91E-10mmHg at 25°C
• Refractive Index: 1.676
• PKA: 10.92±0.40(Predicted)
• CAS DataBase Reference: 6-CHLORO-4-PHENYLQUINAZOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-PHENYLQUINAZOLIN-2(1H)-ONE(4797-43-7)
• EPA Substance Registry System: 6-CHLORO-4-PHENYLQUINAZOLIN-2(1H)-ONE(4797-43-7)

Safety Data

• Hazardous Substances Data: 4797-43-7(Hazardous Substances Data)

Usage

Structure

Quinazolinone derivative containing a chlorine atom and a phenyl group

Pharmacological Properties

Studied for potential anti-tumor activity

Potential Applications

Considered for the development of new pharmaceutical drugs

Research Status

Further investigation required to comprehend its full range of applications and effects

InChI:InChI=1/C14H9ClN2O/c15-10-6-7-12-11(8-10)13(17-14(18)16-12)9-4-2-1-3-5-9/h1-8H,(H,16,17,18)

Upstream product

• 64-17-5 ethanol 
• 117054-14-5 2-Amino-7-chlor-5-phenyl-1,3,4-benzotriazepin 
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• 719-59-5 5-chloro-2-aminobenzophenone 
• 57-13-6 urea 
• 112608-09-0 3-Amino-6-chlor-4-hydroxy-2-oxo-4-phenyltetrahydrochinazolin 
• 136440-59-0 (Z)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 136440-60-3 (E)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 108-86-1 bromobenzene 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 79-22-1 methyl chloroformate 
• 963-39-3 demoxepam 
• 106393-87-7 7-Chlor-5-phenyl-2-piperidino-3H-1,3,4-benzotriazepin 
• 439-14-5 diazepam 

Downstream Products

• 87119-75-3 3,9-Dichloro-5-phenyl-quinazolino[3,2-a]quinazolin-12-one 
• 5185-54-6 2-chloro-4-phenyl-6-chloroquinazoline 
• 104405-56-3 2-amino-5-chloro-4-phenyl-2(1H)-quinazoline 
• 100693-28-5 6-Chloro-2-(3,5-dimethyl-pyrazol-1-yl)-4-phenyl-quinazoline 
• 100672-14-8 2-(6-Chloro-4-phenyl-quinazolin-2-yl)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 100672-17-1 6-Chloro-4-phenyl-2-(3,3,5-trimethyl-2,3-dihydro-pyrazol-1-yl)-quinazoline 
• 100672-19-3 5-Amino-2-(6-chloro-4-phenyl-quinazolin-2-yl)-1,2-dihydro-pyrazol-3-one 
• 100672-22-8 1-(6-Chloro-4-phenyl-quinazolin-2-yl)-4-phenyl-1H-pyrazol-3-ylamine 
• 57370-20-4 6-Chlor-2-hydrazino-4-phenyl-chinazolin 
• 108959-10-0 10-Chloro-8-phenyl-1,6,7,12b-tetraaza-benzo[c]phenanthren-5-one 
• 108959-08-6 2-Chloro-N-(6-chloro-4-phenyl-quinazolin-2-yl)-nicotinamide 
• 37554-40-8 1-(2,2,2-Trifluoroethyl)-4-phenyl-6-chloro-2(1H)-quinazolinone 
• 1188531-63-6 6-chloro-1-(3-iodopropyl)-4-phenylquinazolin-2(1H)-one 

Relevant articles and documents

Laser Induced Fluorometric Analysis of Drugs

Laser induction of molecular fluorescence was investigated for the analysis of intrinsically fluorescent compounds such as quinine sulfate, salicylic acid, caprofen (a carbazole), 2-methoxy-11-oxo-11H-pyrido-quinazoline-8-carboxylic acid, and fluorescent derivatives of nonfluorescent compounds such as the quinazoline produced by the photolysis of demoxepan, the 9-acridanone derivative of flurazepam, and the fluorescamine (Fluram) derivative of amphetamine.The sensitivity limit of reliable quantitation utilizing laser-induced fluorescence was equal to or better than that obtained by a conventional spectrofluorometer.

Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable NAD(P)H Models

A facile approach to chiral dihydroquinazolinone derivatives has been described via biomimetic asymmetric reduction of quinazolinones with chiral and regenerable NAD(P)H models. The utility of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.

SUBSTANCE CAPABLE OF INHIBITING CYTOKININ SIGNALING

Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical subs